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US 7,117,097 B2Granted
Methods, computer software products and systems for correlating gene lists
AssigneeAffymetrix, Inc.
InventorDavid Finkelstein
Life of this patent
Estimating the term…
Abstract
In some embodiment of the invention, methods are provided to compare lists of genes. In one embodiment, the genes are ranked with the lists. The ranks are analyzed using Spearman correlation.
Claims12
A computer implemented method for comparing a plurality of gene expression data sets comprising:
- Providing at least two lists of genes, wherein the lists are obtained from different laboratories;
- Ranking the genes within each list;
- Calculating the Spearman Correlation for the ranks of the genes that are common to more than one list.
A computer implemented method for diagnosing a disease comprising:
- Obtaining gene expression values from a patient sample;
- Comparing the patient sample with a reference sample to detect gene expression changes;
- Ranking the genes according to the expression changes;
- and
- Calculating Spearman Correlation between the ranks of the genes in the patient sample and reference ranks of genes in a disease reference sample.
2 more elements
A computer readable medium having software modules for performing the method of:
- providing at least two lists of genes, wherein the lists are obtained from different laboratories;
- ranking the genes within each list;
- calculating the Spearman Correlation for the ranks of the genes that are common to more than one list.
A computer readable medium having software modules for performing the method of:
- obtaining gene expression values from a patient sample;
- comparing the patient sample with a reference sample to detect gene expression changes;
- ranking the genes according to the expression changes;
- and
- calculating Speanran Correlation between the ranks of the genes in the patient sample and reference ranks of genes in a disease reference sample.
2 more elements
Dependencies are inferred from the claim text.