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US 7,115,777 B2Granted
Amide derivatives as inhibitors of the enzymatic activity of renin
AssigneeNovartis AG
InventorsThomas Allmendinger, Peter Furter
Life of this patent
Estimating the term…
Abstract
The present inventions relates to a novel compound of formula (I) or a pharmaceutically acceptable salt thereof, the use and manufacture of a compound of formula (I) or a pharmaceutical composition comprising a compound of formula (I).
Claims15
A compound of formula (I)
- or a pharmaceutically acceptable salt thereof;
- wherein Y represents the group —C(═X) or SO2;
- and
- (i) R1 and R2 together form a single bond or methylene;
- and, if Y represents the group —C(═X), X represents NH, S, or O;
- or
- (ii) R1 represents C1–C7-alkyl;
- or represents C1–C7-alkyl that is substituted by a substitutent selected from the group consisting of amino, carboxy, hydroxy-C1–C7-alkyl-amino, C1–C7-alkoxy-C1–C7-alkyl-amino, and aryl that is unsubstituted or substituted by a substiuent selected from the group consisting of C1–C7-alkyl, C1–C7-alkoxy, hydroxy, carboxy, halogen, CF3, nitro and cyano;
- or represents C1–C7-alkoxy that is unsubstituted or substituted by a substiuent selected from the group consisting of C1–C7-alkyl, C1–C7-alkoxy, hydroxy, halogen, CF3, nitro and cyano;
- and R2 represents hydrogen;
- and, if Y represents the group —C(═X), X represents NH, S, or O;
- or
- (iii) R1 represents amino;
- R2 represents hydrogen;
- and, if Y represents the group —C(═X), X represents NH;
- or
- wherein Y represents the group —C(═X);
- and
- (iv) R1 and R2 together form a the group —CO—O—;
- and X represents O.
17 more elements
Dependencies are inferred from the claim text.