Pyrrolidine derivatives as oxytocin antagonists

A pyrrolidine derivative of Formula I:

• a geometrical isomer thereof, an optically active form thereof, an enantiomer thereof, a diastereomer thereof, one or more mixtures thereof, a racemate form thereof, or a salt thereof, wherein:
• R1 is selected from the group consisting of H and C1–C6-alkyl;
• R2 is selected from the group consisting of hydrogen, C1–C6-alkyl, C1–C6-alkyl aryl, heteroaryl, C1–C6-alkyl heteroaryl, C2–C6-alkenyl, C2–C6-alkenyl aryl, C2–C6-alkenyl heteroaryl, C2–C6-alkynyl, C2–C6-alkynyl aryl, C2–C6-alkynyl heteroaryl, C3–C8-cycloalkyl, heterocycloalkyl, C1–C6-alkyl cycloalkyl, C1–C6-alkyl heterocycloalkyl, C1–C6-alkyl carboxy, acyl, C1–C6-alkyl acyl, C1–C6-alkyl acyloxy, C1–C6-alkyl alkoxy, alkoxycarbonyl, C1–C6-alkyl alkoxycarbonyl, aminocarbonyl, C1–C6-alkyl aminocarbonyl, C1–C6-alkyl acylamino, C1–C6-alkyl ureido, amino, C1–C6-alkyl amino, sulfonyloxy, C1–C6-alkyl sulfonyloxy, sulfonyl, C1–C6-alkyl sulfonyl, sulfinyl, C1–C6-alkyl sulfinyl, C1–C6-alkyl sulfanyl, and C1–C6-alkyl sulfonylamino;
• R3 is selected from the group consisting of aryl and heteroaryl;
• X is selected from the group consisting of O and NR4;
• R4 is selected from the group consisting of H, C1–C6-alkyl, C1–C6-alkyl aryl, C1–C6-alkyl heteroaryl, aryl and heteroaryl;
• wherein
• R2 and R4 can form together with the N atom to which they are linked to, a 5–8 membered saturated or unsaturated heterocycloalkyl ring;
• and
• n is an integer from 1 to 3.