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US 7,115,748 B2Granted
Method of making imidazole-2-thiones
AssigneeAllergan, Inc.
InventorsMichael E. Garst, Lloyd Jay Dolby, Shervin Esfandiari, Alfred Arthur Avey, Jr.
Life of this patent
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Abstract
The present invention provides a method of making an imidazole-2-thione which comprises the steps of reacting a vicinal diamine with a compound having a thiocarbonyl moiety and oxidizing the resulting reaction product to obtain said imidazole-2-thione.
Claims8
A method of making an imidazole-2-thione which comprises the steps of reacting a vicinal diamine having the formula I
- wherein R is selected from the group consisting of hydrogen, alkyl, alkenyl, alkoxy, carbocyclic aryl and heterocyclic aryl radicals and R1 is selected from the group consisting of hydrogen, alkyl, alkoxy, carbocyclic aryl and heterocyclic aryl, radicals with a compound having a thiocarbonyl moiety to obtain a first reaction product having the general formula II
- reacting said first reaction product with R3—Cl to provide a second reaction product having the formula IV
- wherein R3 is selected from the group consisting of allyl, benzyl, 2, 4 dimethoxybenzyl, 2-methoxy benzyl and acetoxy benzyl and oxidizing said reaction product to obtain an imidazole-2-thione having the formula III
Dependencies are inferred from the claim text.