Solid phase synthesis of novel biaryl triazine library by suzuki cross coupling

A method for preparing a trisubstituted biaryl triazine compound comprising:

• (a) reacting cyanuric chloride with a benzenealkanethiol;
• (b) reacting the product of step (a) with a resin-bound amine;
• (c) reacting the product of step (b) with a arylboronic acid to obtain a trisubstituted biaryl triazine compound;
• (d) reacting the product of step (c) with m-CPBA to obtain a sulfone biaryltriazine;
• and
• (e) reacting the product of step (d) with an amine to produce a trisubstituted biaryltriazine.

A method for preparing a trisubstituted biaryl triazine compound comprising reacting a disubstituted monochiorotriazine of formula 1

• with an aryl boronic acid to produce a diarylsubstituted triazine of formula 3
• wherein R and R1 are selected from the group consisting of phenyl substituted with at least one of F, Cl, methoxy, ethoxy, trifluoromethyl and C1–C6 alkyl, and benzyl substituted with at least one of F, Cl, methoxy, ethoxy, trifluoromethyl, and C1–C6 alkyl;
• and
• X2 is selected from the group consisting of amines;
• alcohols;
• thiols;
• C1–C20 alkyl;
• phenyl substituted with at least one of F, Cl, methoxy, ethoxy, trifluoromethyl and C1–C6 alkyl;
• and benzyl substituted with at least one of F, Cl, methoxy, ethoxy, trifluoromethyl, and C1–C6 alkyl.