Human peroxisome proliferator activated receptor γ
AssigneeLigand Pharmaceutical, Inc.
InventorRanjan Mukherjee
Life of this patent
Estimating the term…
Abstract
The present invention relates to a novel human peroxisome proliferator activated receptor, hPPARγ. hPPARγ differs from the mouse peroxisome proliferator activated receptor γ in the nucleotide sequence and the amino acid sequence. The invention provides isolated, purified, enriched or recombinant nucleic acid encoding hPPARγ polypeptides and vectors containing thereof, cells transformed with such vectors, and methods of screening for agonists and antagonists of hPPARγ polypeptides. The invention also provides isolated, purified, enriched, or recombinant hPPARγ polypeptides, antibodies having specific binding affinity to hPPARγ polypeptides, and hybridomas producing such antibodies.
Claims36
An isolated nucleic acid comprising a contiguous nucleic acid sequence encoding SEQ ID NO:
- 2 and an operably linked promoter.
An isolated nucleic acid comprising a contiguous nucleic acid sequence encoding amino acid residue 18 to 494 of SEQ ID NO:
- 2 and an operably linked promoter.
An isolated nucleic acid comprising a contiguous nucleic acid sequence encoding amino acid residue 20 to 494 of SEQ ID NO:
- 2 and an operably linked promoter.
An isolated nucleic acid comprising a contiguous nucleic acid sequence encoding SEQ ID NO:
- 2.
An isolated nucleic acid comprising a contiguous nucleic acid sequence encoding amino acid residue 18 to 494 of SEQ ID NO:
- 2.
An isolated nucleic acid comprising a contiguous nucleic acid sequence encoding amino acid residue 20 to 494 of SEQ ID NO:
- 2.
A purified or enriched nucleic acid comprising a contiguous nucleic acid sequence encoding SEQ ID NO:
- 2.
A purified or enriched nucleic acid comprising a contiguous nucleic acid sequence encoding amino acid residue 18 to 494 of SEQ ID NO:
- 2.
A purified or enriched nucleic acid comprising a contiguous nucleic acid sequence encoding amino acid residue 20 to 494 of SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.