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US 7,115,725 B2Granted
Multi-mutant diphtheria toxin vaccines
AssigneePresident and Fellows of Harvard College
InventorR. John Collier
Life of this patent
Estimating the term…
Abstract
Disclosed is DNA encoding diphtheria toxin polypeptides having multiple mutations, which render the polypeptides useful as vaccines.
Claims8
DNA encoding a polypeptide comprising a mutant diphtheria toxin C domain, a mutant diphtheria toxin T domain, and a mutant diphtheria toxin R domain,
- said C domain comprising a mutation in Glu148,
- said T domain comprising a mutation in Glu349, and
- said R domain comprising a mutation in one or both of Lys516 and Phe530 of wild-type diphtheria toxin.
Dependencies are inferred from the claim text.