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US 7,115,720 B2Granted
Therapeutic and diagnostic compounds, compositions, and methods
AssigneeNeoRx Corporation
InventorAlan R. Fritzberg
Life of this patent
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Abstract
The invention provides a complex comprising a) a compound formula I: wherein R1, X and n have any of the values described in the specification, or a pharmaceutically acceptable salt thereof; and b) a radionuclide. The complexes are useful as diagnostic agents and as therapeutic agents. The invention also provides methods and intermediates useful for preparing the complexes of the invention, as well as therapeutic and diagnostic methods.
Claims62
A complex comprising:
- a) compound of formula (I):
- wherein:
- each R1 is independently hydrogen or (C1–C4)alkyl, optionally substituted with carboxy;
- each X is independently (CH2)n or
- and each n is independently 2, 3, or 4;
- wherein the compound of formula I is substituted on one or more carbons other than a carbon of R1 with one or more groups —Y(PO3H2)m;
- wherein Y is a linker group;
- and m is 1, 2, 3, 4, 5, or 6;
- or a pharmaceutically acceptable salt thereof;
- and
- b) a detectable or therapeutic radionuclide.
8 more elements
Dependencies are inferred from the claim text.