Anti-TRAIL-R antibodies
AssigneeKirin Beer Kabushiki Kaisha
InventorsEiji Mori, Shiro Kataoka
Life of this patent
Estimating the term…
Abstract
Anti-TRAIL-R1 and R2 antibodies or functional fragments thereof, having at least one property selected from the following (a) to (c) of: (a) having activity to induce apoptosis in carcinoma cells expressing TRAIL-R1 and/or TRAIL-R2; (b) not having effect on normal human cells expressing TRAIL-R1 and/or TRAIL-R2; and (c) not inducing human hepatocyte toxicity.
Claims14
An antibody or antigen binding fragment thereof, said antibody or fragment having the mature portions of:
- a heavy chain variable region and a light chain variable region of SEQ ID NO:
- 17 and SEQ ID NO:
- 19, respectively;
- a heavy chain variable region and a light chain variable region of SEQ ID NO:
- 21 and SEQ ID NO:
- 23, respectively;
- a heavy chain variable region and a light chain variable region of SEQ ID NO:
- 25 and SEQ ID NO:
- 27, respectively;
- a heavy chain variable region and a light chain variable region of SEQ ID NO:
- 29 and SEQ ID NO:
- 31, respectively;
- or
- a heavy chain variable region and a light chain variable region of SEQ ID NO:
- 33 and SEQ ID NO:
- 35, respectively.
An antibody or antigen binding fragment thereof, said antibody or fragment having the mature portions of a heavy chain variable region and a light chain variable region of SEQ ID NO:
- 29 and SEQ ID NO:
- 31, respectively.
An antibody or a functional antigen binding fragment thereof, said antibody or fragment having the mature portions of:
- a heavy chain variable region and a light chain variable region of the antibody produced by a hybridoma E-11-13 with the accession number of FERM BP-7698 or FERM BP-7770;
- a heavy chain variable region and a light chain variable region of the antibody produced by a hybridoma L-30-10 with the accession number of FERM E3P-7700 or FERM BP-7769;
- a heavy chain variable region and a light chain variable region of the antibody produced by a hybridoma H-48-2 with the accession number of FERM BP-7599;
- a heavy chain variable region and a light chain variable region of the antibody produced by a hybridoma 0304 with the accession number of FERM BP-8037;
- or
- a heavy chain variable region and a light chain variable region of the antibody produced by a hybridoma KMTR1 with the accession number of FERM BP-8038.
An antibody or antigen binding fragment thereof, said antibody or fragment having the mature portions of a heavy chain variable region and a light chain variable region of the antibody produced by a hybridoma 0304 with the accession number of FERM BP-8037.
An antibody or antibody binding fragment thereof, said antibody or fragment having the mature portions of a heavy chain variable region and a light chain variable region:
- which are amino acids 27 to 144 of SEQ ID NO:
- 17 and amino acids 21 to 127 of SEQ ID NO:
- 19, respectively;
- which are amino acids 27 to 144 of SEQ ID NO:
- 21 and amino acids 21 to 127 of SEQ ID NO:
- 23, respectively;
- which are amino acids 27 to 152 of SEQ ID NO:
- 25 and amino acids 21 to 129 of SEQ ID NO:
- 27, respectively;
- which are amino acids 20 to 145 of SEQ ID NO:
- 29 and amino acids 21 to 127 of SEQ ID NO:
- 31, respectively;
- or
- which are amino acids 20 to 139 of SEQ ID NO:
- 33 and amino acids 20 to 126 of SEQ ID NO:
- 35, respectively.
An antibody or antigen binding fragment thereof, said antibody or fragment having the mature portions of a heavy chain variable region and a light chain variable region of:
- amino acids 20 to 145 of SEQ ID NO:
- 29 and amino acids 21 to 127 of SEQ ID NO:
- 31, respectively.
An antibody or antigen binding fragment thereof, having the mature portions of:
- a heavy chain variable region and a light chain variable region encoded by the nucleic acids of SEQ ID NO:
- 16 and SEQ ID NO:
- 18, respectively;
- a heavy chain variable region and a light chain variable region encoded by the nucleic acids of SEQ ID NO:
- 20 and SEQ ID NO:
- 22, respectively;
- a heavy chain variable region and a light chain variable region encoded by the nucleic acids of SEQ ID NO:
- 24 and SEQ ID NO:
- 26, respectively;
- a heavy chain variable region and a light chain variable region encoded by the nucleic acids of SEQ ID NO:
- 28 and SEQ ID NO:
- 30, respectively;
- or
- a heavy chain variable region and a light chain variable region encoded by the nucleic acids of SEQ ID NOS:
- 32 and SEQ ID NO:
- 34, respectively.
An antibody or antigen binding fragment thereof, having the mature portions of a heavy chain variable region and a light chain variable region encoded by the nucleic acids of SEQ ID NOS:
- 28 and 30, respectively.
An antibody or antigen binding fragment thereof, having the mature portions of:
- a heavy chain variable region and a light chain variable region encoded by nucleic acids isolated from a hybridoma E-11-13 with the accession number of FERM BP-7698 or FERM BP-7770;
- a heavy chain variable region and a light chain variable region encoded by nucleic acids isolated from a hybridoma E-30-10 with the accession number of FERM BP-7700 or FERM BP-7789;
- a heavy chain variable region and a light chain variable region encoded by nucleic acids isolated from a hybridoma M-48-2 with the accession number of FERM BP-7599;
- a heavy chain variable region and a light chain variable region encoded by nucleic acids isolated from a hybridoma 0304 with the accession number of FERM 6P-8037;
- or
- a heavy chain variable region and a light chain variable region encoded by nucleic acids isolated from a hybridoma KMTR1 with the accession number of FERM BP-8038.
An antibody or antigen binding fragment thereof, having the mature portions of a heavy chain variable region and a light chain variable region encoded by nucleic acids isolated from a hybridoma 0304 with the accession number of FERM BP-8037.
An antibody or antigen binding fragment thereof, having the mature portions of a heavy chain variable region and a light chain variable region:
- which are encoded by nucleotides 108 to 461 of SEQ ID NO:
- 16 and 95 to 415 of SEQ ID NO:
- 18, respectively;
- which are encoded by nucleotides 108 to 46 of SEQ ID NO:
- 20 and 91 to 411 of SEQ ID NO:
- 22, respectively;
- which are encoded by nucleotides 107 to 484 of SEQ ID NO:
- 24 and 91 to 417 of SEQ ID NO:
- 26, respectively;
- which are encoded by nucleotides 112 to 489 of SEQ ID NO:
- 28 and 94 to 414 of SEQ ID NO:
- 30, respectively;
- or
- which are encoded by nucleotides 138 to 497 of SEQ ID NO:
- 32 and 123 to 443 of SEQ ID NO:
- 34, respectively.
An antibody or antigen binding fragment thereof, having the mature portions of a heavy chain variable region and a light chain variable region encoded by nucleotides 112 to 489 of SEQ ID NO:
- 28 and 94 to 414 of SEQ ID NO:
- 30, respectively.
Dependencies are inferred from the claim text.