Anti-idiotype antibodies to MN proteins and MN polypeptides
AssigneeInstitute of Virology of the Slovak Academy of Sciences
InventorsJan Zavada, Silvia Pastorekova, Jaromir Pastorek
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Abstract
Herein disclosed is a novel oncogene named MN or alternatively MN/CA IX. Abnormal expression of the MN gene is shown to signify oncogenesis, and diagnostic/prognostic methods for pre-neoplastic/neoplastic disease to detect or detect and quantitate such abnormal MN gene expression. Also disclosed are methods to treat pre-neoplastic/neoplastic disease involving the MN gene and protein, e.g., methods comprising the use of MN-specific antibodies, anti-idiotype antibodies thereto, and anti-anti-idiotype antibodies, and the use of MN antisense nucleic acids. Further disclosed are methods to identify and block MN binding site(s) and identify MN protein partners(s).
Claims3
An anti-idiotype antibody to an idiotype of a second antibody, wherein said idiotype of said second antibody specifically binds to an epitope of MN protein, wherein said anti-idiotype antibody comprises an internal image corresponding to said epitope of said MN protein, and wherein said MN protein has an amino acid sepuence of SEQ ID NO:
- 2 that is encoded by a nucleic acid selected from the group consisting of:
- (a) SEQ ID NO:
- 1;
- and
- (b) polynucleotides that differ from SEQ ID NO:
- 1 due to the degeneracy of the genetic code.
Dependencies are inferred from the claim text.