US 7,115,664 B2 · Peptidomimetic ligands for cellular receptors and ion channels

Abstract

One aspect of the present invention relates to novel peptidomimetic compounds. A second aspect of the present invention relates to the use of the novel peptidomimetic compounds as ligands—agonists or antagonists—for various cellular receptors, e.g., G-protein-coupled receptors and opioid receptors, and various cellular ion channels, e.g., sodium and calcium. In certain embodiments, compounds of the present invention preferentially or selectively inhibit sodium or calcium ion channels. In certain embodiments, compounds of the present invention preferentially or selectively agonize or antagonize $gm opioid receptors. In certain embodiments, compounds of the present invention preferentially or selectively inhibit sodium or calcium ion channels and agonize or antagonize $gm-opioid receptors

Claims7

Dependent claims

A compound represented by general structure B:

wherein
X represents O or S;
Y represents O or S;
Z represents O or S, or is absent;
R represents independently for each occurrence H;
R1 represents aryl;
R2 represents independently for each occurrence alkyl;
R3 represents H, or alkyl;
R4 represents H, or alkyl;
R5 represents independently for each occurrence aralkyl and;
the stereochemical configuration at any stereocenter of a compound represented by B may be R, S, or a mixture of these configurations.

8 more elements

Dependencies are inferred from the claim text.

Facts

Application

10/203,279Filed 27 Feb 2001 · us provisional application

Priority

16 Mar 2000

Published

US 2005/0080271 A114 Apr 2005

Granted

3 Oct 2006

Term ends

Not estimatedThe source records don’t support an estimate.

Classification16 codes

C07D 295/185
Radicals derived from carboxylic acids: from aliphatic carboxylic acids
A61P 29/02
Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]: without…
C07C 275/26
Derivatives of urea, i.e. compounds containing any of the groups [IMAGE cpc-sch-C07C-0967.gif], the nitrogen atoms not being part of nitro or…:…
C07C 275/28
Derivatives of urea, i.e. compounds containing any of the groups [IMAGE cpc-sch-C07C-0967.gif], the nitrogen atoms not being part of nitro or…:…

Peptidomimetic ligands for cellular receptors and ion channels

Life of this patent

Peptidomimetic ligands for cellular receptors and ion channels

Life of this patent

Abstract

Claims7