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US 7,115,662 B2Granted
Certain 5-alkyl-2-arylaminophenylacetic acids and derivatives
AssigneeNovartis AG
InventorsRoger A Fujimoto, Leslie W McQuire, Benjamin B Mugrage, John H Van Duzer, Daqiang Xu
Life of this patent
Estimating the term…
Abstract
Disclosed are the compounds of formula I wherein R is methyl or ethyl; R1 is chloro or fluoro; R2 is hydrogen or fluoro; R3 is hydrogen, fluoro, chloro, methyl, ethyl, methoxy, ethoxy or hydroxy; R4 is hydrogen or fluoro; and R5 is chloro, fluoro, trifluoromethyl or methyl; and pharmaceutically acceptable salts thereof, as selective COX-2 cyclooxygenase inhibitors; and pharmaceutically acceptable prodrug esters thereof.
Claims18
A compound of formula I
- wherein R is methyl or ethyl;
- R1 is chloro or fluoro;
- R2 is hydrogen or fluoro;
- R3 is hydrogen, fluoro, chloro, methyl, ethyl, methoxy, ethoxy or hydroxy;
- R4 is hydrogen or fluoro;
- and
- R5 is chloro, fluoro, trifluoromethyl or methyl;
- or a pharmaceutically acceptable salt thereof;
- or a pharmaceutically acceptable prodrug ester thereof.
6 more elements
Dependencies are inferred from the claim text.