1,2 diarylbenzimidazoles and their pharmaceutical use

A method for treating a patient suffering from chronic inflammation comprising administering to said patient an effective amount of a benzimidazole compound of formula II

• or a physiologically compatible salt thereof,
• in which
• R1 means a phenyl group optionally substituted with up to three substituents, which are independently of one another selected from the group consisting of F, CI, Br, I, C(NH)NH2, C(NH)NHR4, C(NH)NR4R4′, C(NR4)NH2, C(NR4)NHR4′, C(NR4)NR4R4′, XOH, XOR4, XOCOR4, XOCONHR4, XOCOOR4, XCOR4, XC(NOH)R4, XC(NOR4)R4′, XC(NO(COR4))R4′, XCN, XCOOH, XCOOR4, XCONH2, XCONR4R4′, XCONHR4, XCONHOH, XCONHOR4, XCOSR4, XSR4, XSOR4, XSO2R4, SO2NH2, SO2NHR4, SO2NR4R4′, NO2, XNH2, XNHR4, XNR4R4′, XNHSO2R4, XN(SO2R4)(SO2R4′), XNR4SO2R4′, XNHCOR4, XNHCOOR4, XNHCONHR4, tetrahydro-2,5-dioxopyrrol-1-yl, 2,5-dihydro-2,5-dioxopyrrol-1-yl, 2,5-dihydro-2,5-dioxopyrrol-1-yl, 2,7-dihydro-2,7-dioxoisoindol-1-yl, and R4;
• R2 means a phenyl group optionally substituted with up to three substituents which are independently of one another selected from the group consisting of F, CI, Br,I C(NH)NH2, C(NH)NHR4, C(NH)NR4R4′, C(NR4)NH2, C(NR4)NHR4′, C(NR4)NR4R4′, XOH, XOR4, XOCOR4, XOCONHR4, XOCOOR4, XCOR4, XC(NOH)R4, XC(NOR4)R4′, XC(NO(COR4))R4′, XCN, XCOOH, XCOOR4, XCONH2, XCONR4R4′, XCONHR4, XCONHOH, XCONHOR4, XCOSR4, XSR4, XSOR4, XSO2R4, SO2NH2, SO2NHR4, SO2NR4R4′, NO2, XNHR4, XNR4R4′, XNHSO2R4, XN(SO2R4)(SO2R4′), XNR4SO2R4′XNHCOR4, XNHCOOR4, XNHCONHR4, tetrahydro-2,5-dioxopyrrol-1-yl, 2,5-dihydro-2,5-dioxopyrrol-1-yl, 2,7-dihydro-2,7-dioxoisoindol-1-yl, R4;
• R3 stand for one or two substituents which are each independently on one another selected from the group consisting of hydrogen, F, CI, Br, I, XOH, XOR4, XOCOR4, XOCONHR4, XOCOOR4, XCOR4, XC(NOH)R4, XC(NOR4)R4′, XC(NO(COR4))R4′, XCN, XCOOH, XCOOR4, XCONH2, XCONHR4, XCONR4R4′, XCONHOH, XCONHOR4, XCOSR4, XSR4, XSOR4, XSO2R4, SO2NH2, SO2NHR4, SO2NR4R4′, NO2, XNH2, XNHR4, XNR4R4′, XNHSO2R4, XNR4SO2R4′, XN(SO2R4)(SO2R4′), XNHCOR4, XNHCOOR4, XNHCONHR4, tetrahydro-2,5-dioxopyrrol-1-yl, 2,5-dihydro-2,5-dioxopyrrol-1-yl, 2,7-dihydro-2,7-dioxoisoindol-1-yl, and R4;
• R4 and R4′, independently of one another, mean C1-4perfluoroalkyl, C1-6alkyl, C2-6alkenyl, C2-6alkinyl, C3-7cycloalkyl, (C1-3alkyl-C3-7cycloalkyl), C1-3alkyl-C6-10aryl, or c6-10aryl,
• wherein the C6-10aryl is optionally substituted with one or two substituents selected from F, CI, Br, CH3, C2H5, NO2, OCH3, OC2H5, CF3, and C2F5 or optionally carry an annelated methanediylbisoxy group or ethane-1,2-diylbisoxy group,
• R5 and R5′, independently of one another, mean hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkinyl (wherein in each case a carbon atom is optionally replaced by O, S, SO, SO2, NH, NC1-3alkyl or N C1-3alkanoyl, C3-7cycloalkyl-C0-3alkyl, or C6-10aryl, wherein the mentioned alkyl, alkenyl and alkinyl groups are optionally substituted with one of the previously mentioned cycloalkyls or aryls, wherein all previously mentioned alkyl and cycloalkyl radicals are optionally substituted with up to two substituents selected from CF3, C2F5, OH, O C1-3alkyl, NH2, NHC1-3alkyl, NHC1-3alkanoyl, N(C1-3alkyl)2, N(C1-3alkyl)(C1-3alkanoyl), COOH, CONH2, and COOC1-3alkyl and all previously mentioned aryl groups are optionally substituted with one or two substituents selected from F, CI, Br, CH3, C2H5, NO2, OCH3, OC2H5, CF3, and C2F5 or optionally carry an annelated methanediylbisoxy, or ethane-1,2-diylbisoxy group;
• A means C1-10alkanediyl, C2-10alkenediyl, C2-10alkinediyl, (C0-5 alkanediyl-C3-7 cycloalkanediyl-C0-5 alkanediyl), or (C0-5alkanediylarylene-C0-5alkanediyl), wherein the aryl group is optionally substituted with one or two substituents selected from F, CI, Br, CH3, C2H5, NO2, OCH3, OC2H5, CF3, and C2F5, wherein in the mentioned aliphatic groups, one or two carbon atoms are each optionally replaced by O, NH, NR4, NCOR4, or NSO2R4, and wherein alkyl or cycloalkyl groups are optionally substituted with up to two substituents selected from F, OH, OR4, OCOR4, ═O, NH2, NR4R4′, NHCOR4, NHCOOR4, NHCONHR4, NHSO2R4SH, and SR4;
• B means OCOR5, OCONHR5, OCOOR5, COR5, C(NOH)R5, C(NOR5)R5′, C(NO(COR5))R5′, COOH, COOR5, CONH2, CONHNH2, CONHR5, CONR5R5′, CONHOH, CONHOR5, SO3H, SO2NH2, SO2NHR5, SO2NR5R5′, PO3H, PO(OH)(OR5), PO(OR5)(OR5′), PO(OH)(NHR5), or PO(NHR5)(NHR5′), in each case bonded to a carbon atom or group A;
• or the entire group Y—A—B is N(SO2R4)(SO2R4′) or NHSO2R4;
• X means a bond, CH2, (CH2)2, CH(CH3), (CH2)3, CH(CH2CH3), CH(CH3)CH2, or CH2CH(CH3);
• and
• Y means a bond, O, S, SO, SO2, NH, NR4, NCOR4, or NSO2R4.