Heterocyclic compounds

A compound of the formula (II) wherein:

• X is O;
• m is 0, 1 or 2;
• n is 0, 1 or 2;
• t is 0 or 1;
• L is —CH2— optionally substituted by methyl;
• R1 is chosen from t-butyl, amino, cyclohexyl and phenyl, the phenyl is optionally substituted by one to two Ra;
• R2 is chosen from mono- or di-C1-5 alkyl amino, C1-5 alkylthio, C1-5 alkoxy, C3-7 cycloalkyl, aryl, heteroaryl chosen from thienyl, furanyl, isoxazolyl, oxazolyl, thiazolyl, thiadiazolyl, tetrazolyl, pyrazolyl, pyrrolyl, imidazolyl, pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl, pyranyl, quinoxalinyl, indolyl, benzimidazolyl, benzoxazolyl, benzothiazolyl, benzothienyl, quinolinyl, quinazolinyl and indazolyl and heterocyclyl chosen from aziridinyl, pyrrolidinyl, pyrrolinyl, morpholinyl, thiomorpholinyl, tetrahydrofuranyl, dioxalanyl, piperidinyl and piperazinyl, each optionally substituted by one to three Rb;
• Ra is chosen from methoxy, tert-butoxycarbonyl, fluoro, trifluoromethyl and amino;
• Rb is chosen from C1-5 alkyl, aryloxy, C1-5 alkoxy, C1-5 alkylthio, C1-5 acyl, C2-7 alkoxycarbonyl, C1-5 acyloxy, C1-5 acylamino, sulphonylamino, aminosulfonyl, alkylsulfonyl, carboxy, carboxamide, hydroxy, halogen, trifluoromethyl, nitro, nitrile and amino optionally mono-or-di-substituted by C1-5 alkyl, C1-5 acyl or C2-7 alkoxycarbonyl;
• each R3 is chosen from methyl, methoxy, fluoro, trifluoromethyl, and amino;
• and
• R4 is hydrogen;
• or the pharmaceutically acceptable acids and salts or isomers thereof.

A compound chosen from:

• 1-Cyclohexylmethyl-5-phenylamino-1,3-dihydro-benzoimidazol-2-one;
• 1-Cyclohexylmethyl-5-(3,5-dichloro-phenylamino)-1,3-dihydro-benzoimidazol-2-one;
• 5-(3-Amino-4-methyl-phenylamino)-1-cyclohexylmethyl-1,3-dihydro-benzoimidazol-2-one;
• 1-Cyclohexylmethyl-5-(2-fluoro-phenylamino)-1,3-dihydro-benzoimidazol-2-one;
• 1-Cyclohexylmethyl-5-(2-methoxy-phenylamino)-1,3-dihydro-benzoimidazol-2-one;
• 1-Cyclohexylmethyl-5-(3-trifluoromethyl-phenylamino)-1,3-dihydro-benzoimidazol-2-one;
• 1-Cyclohexylmethyl-5-(4-fluoro-phenylamino)-1,3-dihydro-benzoimidazol-2-one;
• 1-Cyclohexylmethyl-5-o-tolylamino-1,3-dihydro-benzoimidazol-2-one;
• 1-Cyclohexylmethyl-5-(2,4-difluoro-phenylamino)-1,3-dihydro-benzoimidazol-2-one;
• 1-Cyclohexylmethyl-5-(3-fluoro-phenylamino)-1,3-dihydro-benzoimidazol-2-one;
• 1-Cyclohexylmethyl-5-(3,4-difluoro-phenylamino)-1,3-dihydro-benzoimidazol-2-one;
• 1-Phenyl-5-phenylamino-1,3-dihydro-benzoimidazol-2-one;
• 1-Cyclohexylmethyl-6-(4-methyl-piperazin-1-yl)-5-phenylamino-1,3-dihydro-benzoimidazol-2-one;
• 1-Cyclohexylmethyl-5-phenylamino-6-piperazin-1-yl-1,3-dihydro-benzoimidazol-2-one;
• 1-Cyclopentyl-5-(2-fluoro-phenylamino)-6-(4-methyl-piperazin-1-yl)-1,3-dihydro-benzoimidazol-2-one;
• 1-Cyclohexylmethyl-5-(2-fluoro-phenylamino)-6-piperazin-1-yl-1,3-dihydro-benzoimidazol-2-one;
• 1-Cyclohexylmethyl-6-(4-methyl-piperazin-1-yl)-5-o-tolylamino-1,3-dihydro-benzoimidazol-2-one;
• 1-Cyclohexylmethyl-6-[(2-dimethylamino-ethyl)-methyl-amino]-5-o-tolylamino-1,3-dihydro-benzoimidazol-2-one;
• 1-Cyclohexylmethyl-6-[(3-dimethylamino-propyl)-methyl-amino]-5-o-tolylamino-1,3-dihydro-benzoimidazol-2-one;
• 5-anilino-1-benzyl-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(1-phenylethyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(1,2,3,4-tetrahydronaphthalen-1-yl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(2,3-dihydro-1H-inden-1-yl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(pyridin-3-ylmethyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(4-chlorobenzyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(2,6-difluorobenzyl)-1,3-dihydro-2H-benzimidazol-2-one
• 5-anilino-1-(2,4-dichlorobenzyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(2,3-dichlorobenzyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(3-methoxybenzyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(2,6-dimethoxybenzyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(3,5-dimethoxybenzyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(2,4-dimethoxybenzyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(2,3-dimethoxybenzyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(2,5-dimethoxybenzyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(2-methylbenzyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(3,5-dimethylbenzyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(3,4-dimethylbenzyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(2,3-dimethylbenzyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-[2-(trifluoromethyl)benzyl]-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-[3-(trifluoromethyl)benzyl]-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(2-phenylethyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(2-pyridin-2-ylethyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(2-pyridin-3-ylethyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(2-pyridin-4-ylethyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(2-thien-2-ylethyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-[3-(1H-imidazol-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-[3-(2-oxopyrrolidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(2-methoxyethyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(tetrahydrofuran-2-ylmethyl)-1,3-dihydro-2H-benzimidazol-2-one;
• ethyl 3-(5-anilino-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)butanoate;
• 5-anilino-1-tert-butyl-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(1,2-dimethylpropyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-butyl-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-pentyl-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-hexyl-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(cyclopropylmethyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(1-cyclohexylethyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-cyclopentyl-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(4-methylcyclohexyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-[2-(dimethylamino)ethyl]-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(2-morpholin-4-ylethyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(2-pyrrolidin-1-ylethyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(2-piperidin-1-ylethyl)-1,3-dihydro-2H-benzimidazol-2-one;
• tert-butyl 2-(5-anilino-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)ethylcarbamate;
• 5-anilino-1-(3-methoxypropyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-[3-(dimethylamino)propyl]-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-[3-(4-methylpiperazin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(3-morpholin-4-ylpropyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-[(1-ethylpyrrolidin-2-yl)methyl]-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-[2-(1-methylpyrrolidin-2-yl)ethyl]-1,3-dihydro-2H-benzimidazol-2-one;
• and
• ethyl 4-(5-anilino-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidine-1-carboxylate
• or the pharmaceutically acceptable acids and salts or isomers thereof.

A compound chosen from:

• 1-Cyclohexylmethyl-5-p-tolylamino-1,3-dihydro-benzoimidazol-2-one;
• 5-anilino-1-(1-methyl-1-phenylethyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(1-naphthylmethyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(pyridin-2-ylmethyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(pyridin-4-ylmethyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(2-bromobenzyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(3-chlorobenzyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(3,5-dichlorobenzyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(3,4-dichlorobenzyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(2,5-dichlorobenzyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(2-methoxybenzyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(4-methoxybenzyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(3,4-dimethoxybenzyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(3-methylbenzyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(4-methylbenzyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(2,4-dimethylbenzyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(2,5-dimethylbenzyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-[4-(trifluoromethyl)benzyl]-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(thien-2-ylmethyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(2-furylmethyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-[4-(methylsulfonyl)benzyl]-1,3-dihydro-2H-benzimidazol-2-one;
• 4-[(5-anilino-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)methyl]benzenesulfonamide;
• 5-anilino-1-[4-(dimethylamino)benzyl]-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(1,1′-biphenyl-3-ylmethyl)-1,3-dihydro-2H-benzimidazol-2-one;
• methyl 4-[(5-anilino-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)methyl]benzoate;
• 5-anilino-1-(1H-imidazol-4-ylmethyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-tetrahydrofuran-3-yl-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(2-oxotetrahydrofuran-3-yl)-1,3-dihydro-2H-benzimidazol-2-one;
• methyl 2-(5-anilino-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)propanoate;
• 5-anilino-1-isobutyl-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(3-methylbutyl)-1,3-dihydro-2H-benzimidazol-2-one;
• methyl (5-anilino-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)acetate;
• 2-(5-anilino-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)acetamide;
• 5-anilino-1-(2-oxoazepan-3-yl)-1,3-dihydro-2H-benzimidazol-2-one;
• (5-anilino-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)acetonitrile;
• 3-(5-anilino-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)propanenitrile;
• 5-anilino-1-(2-oxo-2-phenylethyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-[2-(1H-imidazol-4-yl)ethyl]-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-[3-(1H-imidazol-4-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one;
• 1-Cyclohexylmethyl-6-[4-(2-oxo-2,3-dihydro-benzoimidazol-1-yl)-piperidin-1-yl]-5-phenylamino-1,3-dihydro-benzoimidazol-2-one;
• 8-[6-anilino-3-(cyclohexylmethyl)-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one;
• 3-[[6-anilino-3-(cyclohexylmethyl)-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl](methyl)amino]propanenitrile;
• 5-anilino-1-(cyclohexylmethyl)-6-[4-(piperidin-1-ylmethyl)piperidin-1-yl]-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(cyclohexylmethyl)-6-[cylohexyl(methyl)amino]-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(cyclohexylmethyl)-6-(4-cyclohexylpiperazin-1-yl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(cyclohexylmethyl)-6-(1,3-thiazolidin-3-yl)-1,3-dihydro-2H-benzimidazol-2-one;
• 2-{4-[6-anilino-3-(cyclohexylmethyl)-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl]piperazin-1-yl}-N-isopropylacetamide;
• 5-anilino-1-(cyclohexylmethyl)-6-pyrrolidin-1-yl-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(cyclohexylmethyl)-6-(4-phenylpiperazin-1-yl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(cyclohexylmethyl)-6-[4-(2-methoxyphenyl)piperazin-1-yl]-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(cyclohexylmethyl)-6-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-1,3-dihydro-2H-benzimidazol-2-one;
• ethyl 4-[6-anilino-3-(cyclohexylmethyl)-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl]piperazine-1-carboxylate;
• 5-anilino-1-(cyclohexylmethyl)-6-(4-methylpiperazin-1-yl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(cyclohexylmethyl)-6-(4-pyridin-4-ylpiperazin-1-yl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(cyclohexylmethyl)-6-thiomorpholin-4-yl-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(cyclohexylmethyl)-6-{4-[2-(dimethylamino)ethyl]piperazin-1-yl}-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(cyclohexylmethyl)-6-piperidin-1-yl-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(cyclohexylmethyl)-6-{4-[3-(dimethylamino)propyl]piperazin-1-yl}-1,3-dihydro-2H-benzimidazol-2-one;
• 6-{4-[2-(aminooxy)ethyl]piperazin-1-yl}-5-anilino-1-(cyclohexylmethyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(cyclohexylmethyl)-6-(2,6-dimethylpiperidin-1-yl)-1,3-dihydro-2H-benzimidazol-2-one;
• 1-[6-anilino-3-(cyclohexylmethyl)-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl]N,N-diethylpiperidine-3-carboxamide;
• ethyl 1-[6-anilino-3-(cyclohexylmethyl)-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl]piperidine-3-carboxylate;
• 1-[6-anilino-3-(cyclohexylmethyl)-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl]piperidine-3-carboxamide;
• 5-anilino-1-(cyclohexylmethyl)-6-(3-methylpiperidin-1-yl)-1,3-dihydro-2H-benzimidazol-2-one;
• ethyl 1-[6-anilino-3-(cyclohexylmethyl)-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl]piperidine-4-carboxylate;
• 5-anilino-1-(cyclohexylmethyl)-6-(4-methylpiperidin-1-yl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(cyclohexylmethyl)-6-(4-pyridin-2-ylpiperazin-1-yl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(cyclohexylmethyl)-6-[methyl(2-pyridin-2-ylethyl)amino]-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-6-(1,4′-bipiperidin-1′-yl)-1-(cyclohexylmethyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(cyclohexylmethyl)-6-[methyl(1-methylpiperidin-4-yl)amino]-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(cyclohexylmethyl)-6-(dimethylamino)-1,3-dihydro-2H-benzimidazol-2-one;
• 6-[allyl(methyl)amino]-5-anilino-1-(cyclohexylmethyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(cyclohexylmethyl)-6-(2,2-dimethyl-1,3-thiazolidin-3-yl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(cyclohexylmethyl)-6-[[2-(dimethylamino)ethyl](methyl)amino]-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(cyclohexylmethyl)-6-[methyl(2-pyridin-4-ylethyl)amino]-1,3-dihydro-2H-benzimidazol-2-one;
• 6-(4-acetylpiperazin-1-yl)-5-anilino-1-(cyclohexylmethyl)-1,3-dihydro-2H-benzimidazol-2-one;
• N-{1-[6-anilino-3-(cyclohexylmethyl)-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl]pyrrolidin-3-yl}-N-methylacetamide;
• 5-anilino-1-(cyclohexylmethyl)-6-[methyl(1-methylpyrrolidin-3-yl)amino]-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(cyclohexylmethyl)-6-(4-methyl-1 ,4-diazepan-1-yl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(cyclohexylmethyl)-6-(4-ethylpiperazin-1-yl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(cyclohexylmethyl)-6-[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]-1,3-dihydro-2H-benzimidazol-2-one;
• tert-butyl 4-[6-anilino-3-(cyclohexylmethyl)-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl]piperazine-1-carboxylate;
• 6-[allyl(cyclopentyl)amino]-5-anilino-1-(cyclohexylmethyl)-1,3-dihydro-2H-benzimidazol-2-one;
• methyl 1-[6-anilino-3-(cyclohexylmethyl)-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl]piperidine-4-carboxylate;
• 5-anilino-1-(cyclohexylmethyl)-6-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(cyclohexylmethyl)-6-[(3 S)-3-(dimethylamino)pyrrolidin-1-yl]-1,3-dihydro-2H-benzimidazol-2-one;
• 1-[6-anilino-3-(cyclohexylmethyl)-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl]-D-prolinamide;
• 5-anilino-1-(cyclohexylmethyl)-6-[4-(3 ,5-dichloropyridin-4-yl)piperazin-1-yl]-1,3-dihydro-2H-benzimidazol-2-one;
• 1-[6-anilino-3-(cyclohexylmethyl)-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl]-1H-pyrrole-2-carbonitrile;
• 6-(4-acetyl-1,4-diazepan-1-yl)-5-anilino-1-(cyclohexylmethyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 3-{4-[6-anilino-3-(cyclohexylmethyl)-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl]piperazin-1-yl}pyrazine-2-carbonitrile;
• 5-anilino-1-(cyclohexylmethyl)-6-(diethylamino)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(cyclohexylmethyl)-6-[4-(3-methoxyphenyl)piperazin-1-yl]-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(cyclohexylmethyl)-6-[4-(4-methoxyphenyl)piperazin-1-yl]-1,3-dihydro-2H-benzimidazol-2-one;
• ethyl {4-[6-anilino-3-(cyclohexylmethyl)-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl]piperazin-1-yl}acetate;
• 5-anilino-6-(4-benzylpiperazin-1-yl)-1-(cyclohexylmethyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(cyclohexylmethyl)-6-(2-methylpiperidin-1-yl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(cyclohexylmethyl)-6-(2-{[(2S)-1-methylpyrrolidin-2-yl]methyl}piperidin-1-yl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(cyclohexylmethyl)-6-morpholin-4-yl-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(cyclohexylmethyl)-6-[4-(tetrahydrofuran-2-ylcarbonyl)piperazin-1-yl]-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(cyclohexylmethyl)-6-(4-hydroxy-4-phenylpiperidin-1-yl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(cyclohexylmethyl)-6-[(cyclopropylmethyl)(propyl)amino]-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(cyclohexylmethyl)-6-[(2-hydroxyethyl)(pentyl)amino]-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-6-[butyl(propyl)amino]-1-(cyclohexylmethyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-6-[bis(2-methoxyethyl)amino]-1-(cyclohexylmethyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(cyclohexylmethyl)-6-(4-pyrimidin-2-ylpiperazin-1-yl)-1,3-dihydro-2H-benzimidazol-2-one;
• tert-butyl 1-[6-anilino-3-(cyclohexylmethyl)-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl]pyrrolidin-3-ylcarbamate;
• 5-anilino-1-(cyclohexylmethyl)-6-(3,5-dimethylpiperidin-1-yl)-1,3-dihydro-2H-benzimidazol-2-one;
• ethyl N-[6-anilino-3-(cyclohexylmethyl)-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl]-N-(2-furylmethyl)-beta-alaninate;
• tert-butyl 4-[6-anilino-3-(cyclohexylmethyl)-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl]-1,4-diazepane-1-carboxylate;
• 5-anilino-1-(cyclohexylmethyl)-6-[methyl(2-phenylethyl)amino]-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(cyclohexylmethyl)-6-[(2-methoxyethyl)(propyl)amino]-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(cyclohexylmethyl)-6-[4-(4-nitrophenyl)piperazin-1-yl]-1,3-dihydro-2H-benzimidazo
• 5-anilino-6-(4-benzyl-1,4-diazepan-1-yl)-1-(cyclohexylmethyl)-1,3-dihydro-2H-benzimidazol-2one;
• 5-anilino-1-(cyclohexylmethyl)-6-[4-(4-hydroxyphenyl)piperazin-1-yl]-1,3-dihydro-2H-benzimidazol-2-one;
• 5-anilino-1-(cyclohexylmethyl)-6-[4-(2-hydroxyphenyl)piperazin-1-yl]-1,3-dihydro-2H-benzimidazol-2-one;
• 6-[allyl(cyclohexyl)amino]-5-anilino-1-(cyclohexylmethyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 3-[[6-anilino-3-(cyclohexylmethyl)-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl](butyl)amino]propanenitrile;
• 5-anilino-1-(cyclohexylmethyl)-6-[[2-(dimethylamino)ethyl](ethyl)amino]-1,3-dihydro-2H-benzimidazol-2-one;
• 1-Cyclohexylmethyl-6-((R)-2-methoxymethyl-pyrrolidin-1-yl)-5-phenylamino-1,3-dihydro-benzoimidazol-2-one;
• tert-butyl 1-[6-anilino-3-(cyclohexylmethyl)-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl]pyrrolidin-3-yl(methyl)carbamate;
• 6-[4-(4-acetylphenyl)piperazin-1-yl]-5-anilino-1-(cyclohexylmethyl)-1,3-dihydro-2H-benzimidazol-2-one;
• 6-(4-Benzyl-piperazin-1-yl)-1-cyclohexylmethyl-5-phenylamino-1,3-dihydro-benzoimidazol-2-one;
• ethyl 1-[6-anilino-3-(cyclohexylmethyl)-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl]-1H-pyrrole-2-carboxylate;
• 1-[4-(2-Dimethylamino-ethoxy)-benzyl]-5-phenylamino-1,3-dihydro-benzoimidazol-2-one;
• 5-(2,4-Difluoro-phenylamino)-1-[4-(2-dimethylamino-ethoxy)-benzyl]-1,3-dihydro-benzoimidazol-2-one;
• 1-(2,6-Difluoro-phenyl)-5-phenylamino-1,3-dihydro-benzoimidazol-2-one;
• 1-Phenyl-5-phenylamino-1,3-dihydro-benzoimidazol-2-one;
• 5-(2,4-Difluoro-phenylamino)-1-phenyl-1,3-dihydro-benzoimidazol-2-one;
• 1-(2,6-Dichloro-phenyl)-5-phenylamino-1,3-dihydro-benzoimidazol-2-one;
• 1-Cyclohexylmethyl-6-(2-dimethylamino-ethylsulfanyl)-5-phenylamino-1,3-dihydro-benzoimidazol-2-one;
• 1-Cyclohexylmethyl-5-(2,4-difluoro-phenylamino)-6-(2-dimethylamino-ethylsulfanyl)-1,3-dihydro-benzoimidazol-2-one;
• 1-Cyclohexylmethyl-6-(2-dimethylamino-ethoxy)-5-phenylamino-1,3-dihydro-benzoimidazol-2-one;
• 1-Cyclohexylmethyl-5-(2,4-difluoro-phenylamino)-6-(2-dimethylamino-ethoxy)-1,3-dihydro-benzoimidazol-2-one;
• 1-Cyclohexylmethyl-6-(2-dimethylamino-ethylamino)-5-phenylamino-1,3-dihydro-benzoimidazol-2-one
• and
• 1-Cyclohexylmethyl-5-(2,4-difluoro-phenylamino)-6-(2-dimethylamino-ethylamino)-1,3-dihydro-benzoimidazol-2one
• or the pharmaceutically acceptable acids and salts or isomers thereof.

A compound chosen from:

• 1-benzyl-5-phenoxy-1,3-dihydro-benzoimidazol-2-one;
• 1-Cyclohexylmethyl-5-phenoxy-1,3-dihydro-benzoimidazol-2-one;
• 1-Benzyl-5-o-tolyloxy-1,3-dihydro-benzoimidazol-2-one;
• 1-tert-Butyl-5-phenoxy-1,3-dihydro-benzoimidazol-2-one;
• 1-Cyclopentyl-5-phenoxy-1,3-dihydro-benzoimidazol-2-one;
• 5-Phenoxy-1-piperidin-4-yl-1,3-dihydro-benzoimidazol-2-one;
• 5-Phenoxy-1-piperidin-4-ylmethyl-1,3-dihydro-benzoimidazol-2-one;
• 1-(2-Amino-ethyl)-5-phenoxy-1,3-dihydro-benzoimidazol-2-one;
• 1-(2-Amino-1,1-dimethyl-ethyl)-5-phenoxy-1,3-dihydro-benzoimidazol-2-one;
• 1-(2-Amino-2-methyl-propyl)-5-phenoxy-1,3-dihydro-benzoimidazol-2-one;
• 1-Cyclohexylmethyl-5-phenylsulfanyl-1,3-dihydro-benzoimidazol-2-one;
• 1-tert-Butyl-5-phenylsulfanyl-1,3-dihydro-benzoimidazol-2-one;
• 1-Cyclopentyl-5-phenylsulfanyl-1,3-dihydro-benzoimidazol-2-one;
• 5-Phenylsulfanyl-1-piperidin-4-yl-1,3-dihydro-benzoimidazol-2-one;
• 5-Phenylsulfanyl-1-piperidin-4-ylmethyl-1,3-dihydro-benzoimidazol-2-one;
• 1-(2-Amino-ethyl)-5-phenylsulfanyl-1,3-dihydro-benzoimidazol-2-one;
• 1-(2-Amino-1,1-dimethyl-ethyl)-5-phenylsulfanyl-1,3-dihydro-benzoimidazol-2-one
• and
• 1-(2-Amino-2-methyl-propyl)-5-phenylsulfanyl-1,3-dihydro-benzoimidazol-2-one
• or the pharmaceutically acceptable acids and salts or isomers thereof.