Hetrocyclic aryl sulphonamides

A compound of the general formula (I)

• in which
• R2 and R3 are identical or different and represent hydrogen, hydroxyl, halogen, nitro, cyano, trifluoromethyl, trifluoromethoxy, (C1–C6)-alkyl, (C1–C6)-alkoxy or a group of the formula
• in which
• R5, R6 and R7 are identical or different and in each case represent hydrogen or (C1–C6)-alkyl, which for its part can be substituted by one or two substituents selected from the group consisting of hydroxyl, halogen, cyano, trifluoromethyl and trifluoromethoxy,
• A represents a five- or six-membered heteroaryl linked via a C atom to the adjacent phenyl ring,
• R1 represents the radical
• in which
• R11 represents the side group of an amino acid, and the amino group in R1 can optionally be mono- or polysubstituted by (C1–C6)alkyl, alkylcarbonyl, or phenyl,
• or
• R1 represents a straight-chain or branched (C1–C5)-alkyl radical, which for its part can be substituted by one or more groups selected from phenyl, piperidinyl, pyridinyl, thiazolyl, thienyl,
• or a group
• in which
• R12 and R13 are identical or different and can represent hydrogen, (C1–C6)alkyl, alkylcarbonyl, an amino protective group, or phenyl,
• or
• R1 represents a radical
• or
• R1 represents a straight-chain or branched (C1–C5)-alkyl radical, which for its part is substituted by a group
• in which
• R14, R15, R16 are identical or different and represent hydrogen or (C1–C6)alkyl
• and
• n can assume the values 2 or 3,
• or
• R1 represents piperidinyl or the radical
• in which
• R12 and R13 have the meaning indicated above,
• n represents a number from 1 to 4 and the ring can be up to trisubstituted in an identical or different manner by halogen, (C1–C6)-alkyl, halogeno-(C1–C6)-alkyl, amino, or hydroxyl,
• R4 represents tert-butyl, which is optionally up to trisubstituted, in an identical or different manner, by hydroxyl, fluorine or chlorine, or
• represents cyclopropyl or cyclobutyl, which are mono- to trisubstituted in an identical or independent manner by halogen or (C1–C6)-alkyl, (C1–C6)-alkyl optionally being substituted by hydroxyl, fluorine or chlorine,
• and in which
• X represents oxygen or sulphur,
• and in which nitrogen-containing heterocycles can also be present as N-oxides,
• or a tautomer, stereoisomer, or mixture of stereoisomers of said compound, or a pharmacologically tolerable salt of said compound, tautomer, stereoisomer, or mixture of stereoisomers.