Benzylpiperidine compound

An optionally N-oxidized benzylpiperidine compound represented by the formula (1):

• wherein
• R1 and R2 are the same or different and each is hydrogen, halogen, cyano, nitro, amino, hydroxy, alkoxy or alkyl,
• n is an integer of 1 to 5,
• X is a bond, an oxygen atom, a sulfur atom, SO or SO2,
• Z is a bond,
• Y1 is a bond,
• A is a 5-membered heteroaryl,
• W is aryl, heteroaryl or thiazoline,
• Y2 is amino, alkylamino, arylamino, arylalkylamino, heteroarylalkylamino, acylamino, acylaminoalkyl, alkoxycarbonylamino, carboxymethylamino, aminoalkylamino, -—NR4CONR5R6, wherein R4, R5 and R6 may be the same or different and each is hydrogen or alkyl, sulfonylamino, —CONR7R8, wherein R7 and R8 may be the same or different and each is hydrogen, alkyl, aryl, arylalkyl or heteroarylalkyl, provided that they are not both hydrogen at the same time, aminoalkyl, alkylaminoalkyl, arylaminoalkyl, heteroarylaminoalkyl, arylalkylaminoalkyl, heteroarylalkylaminoalkyl, cyclic amino, hydrazino, guanidino, amidino, hydroxyamidino, alkoxyamidino, aminomethyleneamino, iminomethylamino, imino or —SR16, wherein R16 is alkyl,
• provided that the above-mentioned aryl, heteroaryl, alkylamino, arylamino, arylalkylamino, heteroarylalkylamino, acylamino, acylaminoalkyl, alkoxycarbonylamino, carboxymethylamino, aminoalkylamino, sulfonylamino, —CONR7R8, aminoalkyl, alkylaminoalkyl, arylaminoalkyl, heteroarylaminoalkyl, arylalkylaminoalkyl, heteroarylalkylaminoalkyl, cyclic amino, hydrazino, guanidino, amidino, aminomethyleneamino, iminomethylamino and imino optionally have substituents selected from halogen, haloalkyl, alkyl, alkoxy, aryl, hydroxy, mercapto, carboxy, nitro, amino and alkylamino, provided that
• when acylamino is aminoalkylcarbonylamino, 1 or 2 substituents are selected from hydroxy, alkyl, hydroxyalkyl, aryl, arylalkyl, heteroarylalkyl, side chain of amino acid and side chain of unnatural amino acid,
• when sulfonylamino is aminoalkylsulfonylamino, 1 or 2 substituents are selected from alkyl, aryl, side chain of amino acid and side chain of unnatural amino acid,
• in the case of aminoalkylamino, the substituents on the alkyl moiety are selected from alkyl, hydroxyalkyl and alkoxyalkyl,
• in the case of cyclic amino, the substituents are selected from amino, acylamino, hydroxy, alkoxy, alkyl, acyl, aryl and arylalkyl,
• in the case of hydrazino, guanidino, amidino, aminomethyleneamino or imino, the substituents are selected from alkyl and phenyl on the substitutable nitrogen atom,
• and nitrogen atom in amide, carbamate or sulfonamide contained in the above-mentioned acylamino, acylaminoalkyl, alkoxycarbonylamino and sulfonylamino may be substituted by alkyl,
• an optical isomer thereof or a pharmaceutically acceptable salt thereof.