4-aminopiperidine and their use as a medicine

A compound of the formula

• in racemic, enantiomeric form or all combinations of these forms, wherein
• R1 is —(CH2)m-Y-Z11 or
• —(CH2)m-Z12,
• Z11 is (C1-C6)alkyl or optionally substituted aryl,
• Z12 is bis-phenyl optionally substituted aryl or -optionally substituted heteroaryl,
• R2 is selected from the group consisting of —C(Y)NHX1, —C(O)X2 and SO2X3;
• R3 is selected from the group consisting of hydrogen, an optionally substituted alkyl, alkenyl and alkynyl,
• X1 is selected from the group consisting of (C1-C15)alkyl, alkenyl, alkynyl, —(CH2)m-Y-Z21 and —(CH2)pZ22,
• Z21 is (C1-C6)alkyl
• Z22 is selected from the group consisting of cyclohexenyl, indanyl, bis-phenyl, (C3-C7)cycloalkyl and (C3-C7)heterocycloalkyl, aryl and heteroaryl optionally substituted
• X2 is selected from the group consisting of alkenyl optionally substituted by phenyl optionally substituted, alkynyl, —(CH2)m-W-(CH2)q-Z23 and —(CH2)p-U-Z24 wherein
• Z23 is (C1-C6)alkyl or aryl optionally substituted;
• Z24 is selected from the group consisting of cyclohexenyl, bis-phenyl, (C3-C7)cycloalkyl optionally substituted, (C3-C7)heterocycloalkyl, cyano, amino, mono and di-alkylamino, aryl and heteroaryl optionally substituted,
• X3 is selected from the group consisting of (C1-C10)alkyl, alkenyl optionally substituted by phenyl optionally substituted, —CF3, and
• —(CH2)pZ25,
• Z25 is aryl optionally substituted,
• Y is oxygen or sulfur,
• W is oxygen or sulfur or SO2;
• U is a covalent bond or oxygen;
• n is an integer from 0 to 4;
• m is an integer from 1 to 6;
• p is an integer from 0 to 6;
• q is an integer from 0 to 2,
• and their addition salts with pharmaceutically acceptable acids.