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US 7,115,625 B2Granted
Treatment of cardiovascular and related pathologies
AssigneeMedicure International Inc.
InventorsRajat Sethi, Wasimul Haque
Life of this patent
Estimating the term…
Abstract
Methods for treating cardiovascular and related diseases such congestive heart failure are described. The methods are directed to concurrently administering a compound such as pyridoxal-5′-phosphate, pyridoxamine, pyridoxal, or a 3-acylated pyridoxal analogue with a therapeutic cardiovascular compound.
Claims12
A method of treating congestive heart failure in a mammal comprising:
- concurrently administering to the mammal a therapeutically effective amount for treating congestive heart failure of a combination of a compound selected from the group consisting of pyridoxal-5′-phosphate, pyridoxal, pyridoxamine, a 3-acylated pyridoxal analogue, a pharmaceutically acceptable acid addition salt thereof, and a mixture thereof, and a therapeutic cardiovascular compound selected from the group consisting of an angiotensin converting enzyme inhibitor, an angiotensin II receptor antagonist, a vasodilator, a diuretic, an α-adrenergic receptor antagonist, and a mixture thereof,
- wherein the 3-acylated pyridoxal analogue is a compound of the formula
- wherein
- R1 is a straight or branched alkyl group, a straight or branched alkenyl group, in which an alkyl or alkenyl group may be interrupted by a nitrogen or oxygen atom;
- an alkoxy group;
- a dialkylamino group;
- or an unsubstituted or substituted aryl group;
- and
- R2 is a secondary amino group.
6 more elements
A method of treating congestive heart failure in a mammal comprising:
- concurrently administering to the mammal a therapeutically effective amount for treating congestive heart failure of a combination of a therapeutic cardiovascular compound selected from the group consisting of a calcium channel blocker, a β-adrenergic receptor antagonist, and a mixture thereof, and a compound selected from the group consisting of pyridoxal-5′-phosphate, pyridoxal, pyridoxamine, a 3-acylated pyridoxal analogue, a pharmaceutically acceptable acid addition salt thereof, and a mixture thereof,
- wherein the 3-acylated pyridoxal analogue is a compound of the formula
- wherein
- R1 is a straight or branched alkyl group, a straight or branched alkenyl group, in which an alkyl or alkenyl group may be interrupted by a nitrogen or oxygen atom;
- an alkoxy group;
- a dialkylamino group;
- or an unsubstituted or substituted aryl group;
- and
- R2 is a secondary amino group.
6 more elements
Dependencies are inferred from the claim text.