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US 7,115,622 B2Granted
Amido ether substituted imidazoquinolines
Assignee3M Innovative Properties Company
InventorsStephen L. Crooks, George W. Griesgraber, Philip D. Heppner, Bryon A. Merrill
Life of this patent
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Abstract
Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain ether and amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
Claims12
A compound of the formula (I):
- wherein:
- X is —CH2—CH2—;
- R1 is —R4—NR7—CR3—R6-aryl;
- R2 is selected from the group consisting of C1-4 alkyl, 2-methoxyethyl, and ethoxymethyl;
- R3 is ═O;
- R4 is ethylene;
- R6 is a bond;
- R7 is H;
- and
- n is 0;
- or a pharmaceutically acceptable salt thereof.
8 more elements
Dependencies are inferred from the claim text.