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US 7,115,620 B2Granted
1,3-disubstituted-2-thioxo-imidazolidine-4,5-diones as potassium channel openers
AssigneeWyeth
InventorsJohn A Butera, Hassan M Elokdah, Theodore S Sulkowski, John L Primeau, Joseph R Lennox, Russell F Graceffa
Life of this patent
Estimating the term…
Abstract
Compounds of Formula I are provided: wherein: R is lower alkyl or branched lower alkyl; and Ar is phenyl, phenyl substituted with one or more of halogen, lower alkyl, lower alkoxy, lower alkylthio, lower alkylamino, cyano, or perfluoroalkoxy, or a heteroaromatic moiety; and pharmaceutically acceptable salts thereof.
Claims16
A compound of Formula I:
- wherein:
- R is branched lower alkyl;
- and
- Ar is phenyl substituted with one or more of halogen, lower alkyl, lower alkoxy, lower alkylthio, lower alkylamino, cyano, or perfluoroalkoxy or a pharmaceutically acceptable salt thereof.
1 more element
The compound of Formula I wherein:
- R is C4–C6 branched lower alkyl;
- and
- Ar is phenyl substituted with one or more halogen, cyano, or lower alkyl.
A pharmaceutical composition comprising a pharmaceutically acceptable carrier and an effective amount of a compound of Formula I:
- wherein:
- R is branched lower alkyl;
- and
- Ar is phenyl substituted with one or more of halogen, lower alkyl, lower alkoxy, lower alkylthio, lower alkylamino, cyano, or perfluoroalkoxy or a pharmaceutically acceptable salt thereof.
1 more element
Dependencies are inferred from the claim text.