Arylsulfonamides as antiviral agents

A compound of the general formula (I)

• in which
• R2 and R3 are identical or different and represent hydrogen, hydroxyl, halogen, nitro, cyano, trifluoromethyl, trifluoromethoxy, (C1–C6)-alkyl, (C1–C6)-alkoxy or represent a group of the formula
• in which
• R5, R6 and R7 are identical or different and each represents hydrogen or (C1–C6)-alkyl which for its part may be substituted by one or two substituents selected from the group consisting of hydroxyl, halogen, cyano, trifluoromethyl and trifluoromethoxy,
• A represents five- or six-membered heteroaryl, which is attached to the adjacent phenyl ring via a C atom and has one to three heteroatoms selected from the group consisting of N, O and S,
• R1 represents (C6–C10)-aryl, 5- to 10-membered heteroaryl or 5- to 10-membered heterocyclyl having in each case one to three heteroatoms selected from the group consisting of N, O and S, where
• R1 may be substituted by up to three substituents selected from the group consisting of hydroxyl, amino, mono-(C1–C6)-alkylamino, di-(C1–C6)-alkylamino, halogen, nitro, cyano, oxo, (C1–C6)-alkyl which for its part may be substituted by amino or hydroxyl, (C1–C6)-alkoxy, phenyl, 5- or 6-membered heterocyclyl having up to two heteroatoms selected from the group consisting of N, O and S, 5- or 6-membered heteroaryl having one or more heteroatoms selected from the group consisting of N, O and S, —C(O)—O—R8, —C(O)—NR9R10, —NH—C(O)—R11, —NH—C(O)—C(O)—R12 and —NH—SO2—R13,
• where
• R8, R9 and R10 are identical or different and each represents hydrogen or (C1–C6)-alkyl, or
• R9 and R10 together with the nitrogen atom to which they are attached form a 5- or 6-membered heterocycle which may contain a further nitrogen or oxygen heteroatom and which may be mono- or disubstituted by identical or different substituents from the group consisting of (C1–C4)-alkyl which for its part is optionally substituted by hydroxyl or amino, amino, hydroxyl, (C1–C4)-alkoxy, oxo, carboxyl and (C1–C4)-alkoxycarbonyl,
• R11 and R12 are identical or different and each represents trifluoromethyl, (C1–C6)-alkoxy, or hydroxyl or represents (C1–C6)-alkyl which is optionally mono- or disubstituted by identical or different constituents from the group consisting of amino, (C1–C6)-alkoxycarbonylamino, mono-(C1–C6)-acylamino, hydroxyl, amidino, guanidino, (C1–C6)-alkoxycarbonyl, carboxyl and phenyl, and
• R13 represents (C1–C6)-alkyl or (C6–C10)-aryl which may in each case be substituted by halogen, amino, hydroxyl, (C1–C4)-alkoxy or (C1–C4)-alkyl,
• R4 represents (C1–C6)-alkyl which may be substituted up to three times by identical or different substituents from the group consisting of amino, hydroxyl, halogen, (C1–C6)-alkoxy, (C1–C5)-alkanoyloxy and phenyl, which for its part is optionally mono- or disubstituted by identical or different substituents from the group consisting of halogen, nitro, cyano, amino and hydroxyl,
• or represents (C3–C7)-cycloalkyl which may be substituted up to three times by identical or different substituents from the group consisting of amino, hydroxyl, halogen, (C1–C6)-alkoxy and (C1–C6)-alkyl, which for its part is optionally substituted up to three times by identical or different substituents from the group consisting of amino, hydroxyl, halogen and (C1–C6)-alkoxy,
• or represents (C6–C10)-aryl which is optionally mono- or disubstituted by identical or different substituents from the group consisting of halogen, nitro, cyano, amino and hydroxyl,
• and in which
• X represents oxygen or sulphur,
• and in which nitrogen-containing heterocycles may also be present as N-oxides,
• or a tautomer, steroisomer, mixture of steroisomer, or pharmacologically acceptable salt thereof.