Substituted heterocyclic compounds

A compound of Formula I:

• wherein:
• R1, R2, R3, R4, R5, R6, R7, and R8 are hydrgen, lower alkyl, or —C(O)R, in which R is —OR11 or —NR11R12, where R11 and R12 are independently hydrogen or lower alkyl;
• or
• R1 and R2, R3 and R4, R5 and R6, R7 and R8, when taken together with the carbon to which they are attached, represent carbonyl;
• or with the provisos that
• i. the maximum number of carbonyl groups is 1, and
• ii. the maximum number of —C(O)NR11R12 groups is 1,
• R9 is a mono or bicyclic and may be optionally substituted with 1 to 5 substituents selected from substituted alkyl, phenyl, and phenyl substituted with 1 to 3 substituents selected from amino, alkoxy, hydroxy, halogen and CF3;
• R10 is benzothiazol-5-yl optionally substituted with alkyl;
• T is —O—, —S—, —NHSO2—, —SO2NH—, or —CO—NH—;
• Q is —N<
• X is a covalent bond or an optionally substituted alkylene of 1–6 carbon atoms;
• Y is optionally substituted aikylene of 1–3 carbon atoms;
• and
• Z is a covalent bond, —O—, —S—, or —N(R15)—, wherein R15 is hydrogen or C1-4 alkyl.