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US 7,115,605 B2Granted
Peptide deformylase inhibitors
AssigneeSmithKline Beecham Corporation
InventorsKelly M. Aubart, Siegfried B. Christensen, IV, Jacques Briand, Maxwell David Cummings
Life of this patent
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Abstract
PDF inhibitors and novel methods for their use are provided.
Claims16
A method of treating a bacterial infection by administering a compound according to formula (I):
- wherein
- X is C or O
- n is 1 or 2, and
- Ar is an aryl group selected from the group consisting of phenyl, azaindolyl, pyridyl, indolyl, quinolinyl, pyrazinyl, benzenethiophenyl, isoxazolyl, isoquinolinyl, napthyl, oxazolyl, isothiazolyl, benzothiaphenyl, furyl, pyridazinyl, thienyl, benzofuryl, imidazolyl, and thiazolyl, wherein Ar may be optionally substituted with one, two, or three substituents selected from the group consisting of optionally substituted alkyl or cycloalkyl of one to nine carbons, halo, alkoxy of one to nine carbons, hydroxy, amino, hydroxyalkyl of one to nine carbons, alkoxyalkyl, wherein the alkyl and alkylene groups are independently of one to nine carbons, optionally substituted aryl or optionally substituted heteroaryl, azaindolyl, carboxy, and alkoxycarbonyl or a pharmaceutically acceptable salt thereof.
1 more element
Dependencies are inferred from the claim text.