Heterocycles 3
AssigneeBayer Aktiengesellschaft
InventorsCristina Alonso-Alija, Heike Gielen, Martin Hendrix, Dagmar Schauss, Hilmar Bischoff, Nils Burkhardt, Volker Geiss, Karl-Heinz Schlemmer, Nigel J. Cuthbert, Mary F. Fitzgerald, Graham Sturton
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Abstract
The invention relates to 7-(4-tert butyl-cyclohexyl)-imidazotriazinones, processes for their preparation and their use in medicaments, esp. for the treatment and/or prophylaxis of inflammatory processes and/or immune diseases.
Claims13
A compound of the general formula (I),
- in which
- R1 denotes (C6-C10)-aryl, which is optionally substituted by identical or different residues selected from the group consisting of halogen, (C1-C4)-alkyl, trifluoromethyl, cyano, nitro and trifluoromethoxy, or
- denotes (C1-C8)-alkyl, which is optionally substituted by 3- to 10-membered carbocyclyl, or
- denotes 3- to 10-membered carbocyclyl, which is optionally substituted by identical or different (C1-C4)-alkyl residues, and
- R2 denotes 4-tert-butyl-cyclohex-1-yl, or a salt, hydrate, or solvate thereof.
The compound 7-(cis-4-tert-butylcyclohexyl)-5-ethyl-2-phenylimidazo[5,1-f][1,2,4]triazin-4(3H)-one:
A method of treating chronic obstructive pulmonary disease or asthma, comprising administering to a mammal an effective amount of 7-(cis-4-tert-butylcyclohexyl)-5-ethyl-2-phenylimidazo[5,1-f][1,2,4]triazin-4(3H)-one.
A process for the preparation of 7-(cis-4-tert-butylcyclohexyl)-5-ethyl-2-phenylimidazo[5,1-f][1,2,4]triazin-4(3H)-one, comprising reacting cis-4-tert-butyl-N-[1-(5-oxo-3-phenyl-4,5-dihydro-1,2,4-triazin-6-yl)propyl]cyclo-hexanecarboxamide with phosphoroxychloride.
The compound 7-(cis-4-tert-butylcyclohexyl)-5-ethyl-2-(3-fluorophenyl)imidazo [5,1-f][1,2,4]triazin-4(3H)-one:
A method of treating chronic obstructive pulmonary disease or asthma, comprising administering to a mammal an effective amount of 7-(cis-4-tert-butylcyclohexyl)-5-ethyl-2-(3-fluorophenyl)imidazo [5,1-f][1,2,4]triazin-4(3H)-one.
A process for the preparation of 7-(cis-4-tert-butylcyclohexyl)-5-ethyl-2-(3-fluorophenyl)imidazo[5,1-f][1,2,4]triazin-4(3H)-one, comprising reacting 6-(1-aminopropyl)-3-(3-fluorophenyl)-1,2,4-triazin-5(4H)-one with 4-tert-butyl-cyclohexanecarbonyl chloride and phosphoroxychloride.
Dependencies are inferred from the claim text.