US 7,115,588 B2 · Methods for treating a breach or puncture in a blood vessel

Abstract

The present invention relates to compositions comprising semi-crystalline β-1-4-N-acetylglucosamine polymers (p-GlcNac) and methods utilizing such polymers modulation of vascular structure and/or function. The compositions and methods disclosed are useful for stimulating, in a p-GlcNac concentration-dependent manner, endothelin-1 release, vasoconstriction, and/or reduction in blood flow out of a breached vessel, as well as for contributing to or effecting cessation of bleeding. The methods of the present invention comprise topical administration of materials comprising semi-crystalline p-GlcNac polymers that are free of proteins, and substantially free of single amino acids as well as other organic and inorganic contaminants, and whose constituent monosaccharide sugars are attached in a β-1-4 conformation.

Claims19

Dependent claims

A method for treating a breach or puncture in a blood vessel in a patient, which breach or puncture is caused by a cardiac catheterization or balloon angioplasty procedure, comprising

applying directly to the patient's skin in conjunction with compression at the site of the blood vessel puncture a film or membrane containing an amount of semi-crystalline poly-β-1→4 N-acetylglucosamine polymer, comprising up to about 150,000 N-acetylglucosamine monosaccharides covalently attached in a β-1→4 conformation effective to produce a cessation or reduction of blood flow out of the breach or puncture,
thereby treating said breach or puncture.

Dependencies are inferred from the claim text.

Facts

Application

10/194,740Filed 12 Jul 2002 · continuation

Priority

12 Feb 2001

Published

US 2003/0078234 A124 Apr 2003

Granted

3 Oct 2006

Term ends

Not estimatedThe source records don’t support an estimate.

Classification16 codes

A61K 31/726
Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers,…:…
A61K 9/0014
Galenical forms characterised by the site of application: skin, i.e. galenical aspects of topical compositions
A61K 9/7007
Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug: drug-containing films, membranes or sheets
A61K 31/715
Carbohydrates; Sugars; Derivatives thereof: polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic…

Methods for treating a breach or puncture in a blood vessel

Life of this patent

Methods for treating a breach or puncture in a blood vessel

Life of this patent

Abstract

Claims19