Aripiprazole complex formulation and method
AssigneeBristol-Myers Squibb Company
InventorsManoj Nerurkar, Vijay Naringrekar
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Abstract
An aripiprazole formulation is provided which includes the antipsychotic agent aripiprazole in the form of an inclusion complex in a β-cyclodextrin, preferably, sulfobutyl ether β-cyclodextrin (SBECD), which in the form of an injectable produces reversible generally minimal to mild irritation at the intramuscular injection site. A method for minimizing or reducing irritation caused by aripiprazole at an intramuscular injection site and a method for treating schizophrenia employing the above formulation are also provided.
Claims24
An inclusion complex of aripiprazole in a substituted beta-cyclodextrin.
A pharmaceutical formulation comprising aripiprazole and a substituted β-cyclodextrin.
An aqueous injectable formulation comprising aripiprazole, SBECD, tartaric acid, sodium hydroxide and water, said formulation having a pH within the range for about 4 to about 4.6.
Dependencies are inferred from the claim text.