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US 7,115,582 B2Granted
HoxD3 and HoxA3 compositions and methods for improved wound healing
AssigneeThe Regents of the University of California
InventorsNancy Boudreau, David M. Young, Cornelia Myers
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Abstract
The present invention provides methods and compositions useful in localized transfer of genetic material or proteins. Moreover, the present invention provides methods and compositions for improving and/or controlling wound healing by applying a wound care device comprising HoxD3 and/or HoxA3. In addition, the present invention provides methods and compositions for improved wound healing in subjects having impaired healing capabilities, such as diabetic subjects.
Claims18
A method comprising:
- a) providing;
- i) a subject with a diabetic skin wound, and
- ii) a composition comprising a gene delivery vehicle and an expression vector comprising HoxA3 nucleic acid encoding a HoxA3 protein, wherein said HoxA3 protein is the protein set forth in SEQ ID NO:15 or a biologically active variant thereof that differs by less than 1%;
- and
- b) applying said composition to said wound under conditions suitable for transfecting at least one cell of said wound with said expression vector.
2 more elements
A method comprising:
- a) providing;
- i) a subject with a diabetic skin wound, and
- ii) a composition comprising a cellulosic material and an expression vector comprising HoxA3 nucleic acid encoding the HoxA3 protein set forth in SEQ ID NO:15;
- and
- b) applying said composition to said wound under conditions suitable for transfecting at least one cell of said wound with said expression vector.
2 more elements
Dependencies are inferred from the claim text.