Retro-inverso peptides derived from interleukin-3
AssigneeMyelos Corporation
InventorsDavid E. Wright, D. Elliott Parks
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Abstract
Retro-inverso peptides derived from interleukin-3 (IL-3) having between 12 and about 40 amino acids and including the sequence shown in SEQ ID NO: 1. These peptides have the same activity as native IL-3 and also have neurotrophic activity. Because of the D-amino acid linkage in the peptides, they are less susceptible to proteolytic degradation in vivo.
Claims9
A retro-inverso peptide having between 12 and about 40 amino acids, wherein said peptide comprises the sequence D-Leu-D-Asn-D-Pro-D-Arg-D-Arg-D-Leu-D-Asn-D-Asn-D-Glu-D-Met-D-Leu-D-Ile.
A composition comprising a retro-inverso peptide having between 12 and about 40 amino acids, wherein said peptide comprises the sequence D-Leu-D-Asn-D-Pro-D-Arg-D-Arg-D-Leu-D-Asn-D-Asn-D-Glu-D-Met-D-Leu-D-Ile.
Dependencies are inferred from the claim text.