Cloning and characterization of a human adenylyl cyclase

A method for identifying a candidate compound which binds to a polypeptide selected from the group consisting of:

• a) a polypeptide comprising the amino acid sequence of SEQ ID NO:2;
• b) a polypeptide encoded by the nucleotide sequence set forth in SEQ ID NO:1;
• and
• c) a polypeptide encoded by nucleotides 145–3648 of the nucleotide sequence set forth in SEQ ID NO:1;
• the method comprising:
• i) contacting a sample comprising the polypeptide with a test compound under conditions suitable for binding;
• and
• ii) detecting binding of the test compound to the polypeptide;
• thereby identifying a compound which binds to the polypeptide.