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AssigneeThe Regents of the University of California
InventorQun-Yong Zhou
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The invention provides methods of modulating gastric acid secretion by administering an amount of a prokineticin receptor antagonist effective to alter one or more indicia of gastric acid secretion, wherein the antagonist contains an amino acid sequence at least 80% identical to amino acids to 7 to 77 of SEQ ID NO:3, which includes (a) the 10 conserved cysteine residues of SEQ ID NO:3, and (b) from 0 to 9 of amino acids 78 to 86 of SEQ ID NO:3, wherein amino acids 1 to 6 of the antagonist do not consist of amino acids AVITGA (SEQ ID NO:21). In another embodiment, the antagonist contains an amino acid sequence at least 80% identical to amino acids to 7 to 77 of SEQ ID NO:6, which includes (a) the 10 conserved cysteine residues of SEQ ID NO:6, and (b) from 0 to 4 of amino acids 78 to 81 of SEQ ID NO:6, wherein amino acids 1 to 6 of the antagonist do not consist of amino acids AVITGA (SEQ ID NO:21).
A method of reducing gastric acid or pepsinogen secretion, comprising administering to an animal an amount of a prokineticin receptor antagonist effective to reduce one or more indicia of gastric acid or pepsinogen secretion, wherein said antagonist comprises an amino acid sequence having at least 80% identity to amino acids to 7 to 77 of SEQ ID NO:
A method of reducing gastric acid secretion, comprising administering to an animal an amount of a prokineticin receptor antagonist effective to reduce one or more indicia of gastric acid secretion, wherein said antagonist comprises an amino acid sequence having at least 80% identity to amino acids to 7 to 77 of SEQ ID NO:6, said sequence comprising;
Dependencies are inferred from the claim text.