Use of anti-prolactin agents to treat proliferative conditions
AssigneeGreenville Hospital System
InventorsWen Y. Chen, Thomas E. Wagner
Life of this patent
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Abstract
The present invention relates to variant forms of human prolactin which act as antagonists at the prolactin receptor, and to the use of such variants in the treatment of human cancers and proliferative disorders, including both benign and malignant diseases of the breast and prostate.
Claims15
A method of inhibiting in a subject the proliferation of a breast cancer cell which expresses a prolactin receptor, comprising exposing the cell to an effective concentration of a variant of human prolactin wherein the variant consists of human prolactin and has the substitution of the glycine at position 129.
A method of treating in a subject a breast tumor cell which expresses a prolactin receptor, comprising exposing the cell to an effective concentration of a variant of human prolactin wherein the variant consists of human prolactin and has the having a substitution of the glycine at position 129.
Dependencies are inferred from the claim text.