Methods of increasing myotube formation or survival or muscle cell mitogenesis differentiation or survival using neuregulin GGF III
AssigneeAcorda Therapeutics, Inc.
InventorsRobert Sklar, Mark Marchionni, David I. Gwynne
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Abstract
The invention relates to methods of treating diseases and disorders of the muscle tissues in a vertebrate by the administration of compounds which bind the p185erbB2 receptor. These compounds are found to cause increased differentiation and survival of cardiac, skeletal and smooth muscle.
Claims35
The method of increasing the myotube formation, myotube survival, muscle cell mitogenesis, or muscle cell survival in a mammal in need thereof, said method comprising administering GGF-III polypeptide to said mammal in an amount effective for increasing said myotube formation, myotube survival, muscle cell mitogenesis, or muscle cell survival.
The method of increasing the myotube formation, myotube survival, muscle cell mitogenesis, or muscle cell survival in a mammal in need thereof, said method comprising administering GGF-III polypeptide to said mammal in an amount effective for decreasing muscle atrophy.
The method of increasing the myotube formation, myotube survival, muscle cell mitogenesis, or muscle cell survival in a mammal in need thereof, said method comprising administering GGF-III polypeptide to said mammal in an amount effective for increasing muscle cell mitogenesis.
The method of increasing the myotube formation, myotube survival, muscle cell mitogenesis, or muscle cell survival in a mammal in need thereof, said method comprising administering an effective amount of a GGF-III polypeptide to a mammal lacking a neurotrophic factor.
The method of increasing the myotube formation, myotube survival, muscle cell mitogenesis, or muscle cell survival in a mammal in need thereof, said muscle cell being a satellite cell, said method comprising administering an effective amount of a GGF-III polypeptide to said mammal.
Dependencies are inferred from the claim text.