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AssigneeGenentech, Inc.
InventorsAudrey Goddard, Paul J. Godowski, Austin L. Gurney, Jean-Philippe F. Stephan, Colin K. Watanabe, William I. Wood
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Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
An isolated nucleic acid encoding polypeptide having at least 95% sequence identity to:
An isolated nucleic acid comprising:
An isolated nucleic acid molecule consisting of an at least 30 nucleotide fragment of the nucleic acid sequence of SEQ ID NO:345, or the complement thereof that specifically hybridizes under stringent conditions to:
Dependencies are inferred from the claim text.