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US 7,115,414 B2Granted
Vanilloid receptor-related nucleic acids and polypeptides
AssigneesIRM LLC, a Delaware LLC, Novartis AG
InventorsStuart Bevan, Pamposh Ganju, Peter McIntyre, Ardem Patapoutian, Andrea Peier, Chuanzheng Song
Life of this patent
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Abstract
This invention provides novel genes and polypeptides of the VR family, identification of trkA+ pain specific genes expressed in the DRG, and use of these genes and polypeptides for the treatment of pain and identification of agents useful in the treatment of pain.
Claims18
An isolated TRPV3 nucleic acid molecule comprising a member selected from the group consisting of:
- a) a polynucleotide that encodes a mouse TRPV3 protein comprising amino acid residues 1–791 of SEQ ID NO:
- 2;
- b) a polynucleotide that encodes a mouse TRPV3 protein comprising amino acid residues 2–791 of SEQ ID NO:
- 2;
- c) a polynucleotide that encodes a human TRPV3 protein comprising amino acid residues 1–791 of SEQ ID NO 5;
- d) a polynucleotide that encodes a human TRPV3 protein comprising amino acid residues 2–791 of SEQ ID NO 5;
- and
- e) a polynucleotide that is complementary to the full length of a polynucleotide of a) through d).
5 more elements
A TRPV3 nucleic acid molecule encoding a polypeptide that comprises one or more functional domains selected from the group consisting of:
- a) an ankyrin domain;
- b) a transmembrane region;
- c) a pore loop region;
- and
- d) a coiled-coil domain:
- wherein the polypeptide is a vanilloid receptor, and wherein the polypeptide comprises an amino acid sequence that is at least 98% identical to SEQ ID NO:
- 5, or an amino acid sequence that is at least 98% identical to SEQ ID NO:
- 2 and comprises amino acids 261 to 293 of SEQ ID NO:
- 2.
6 more elements
Dependencies are inferred from the claim text.