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US 7,115,399 B2Granted
Pinna reflex assay
AssigneeAllergan, Inc.
InventorJennifer A. Jenkins
Life of this patent
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Abstract
Method for measuring potency of a substance, the method including; administering the substance to a mammal; subjecting the mammal to a stimulus; and monitoring a pinna reflex response of the mammal.
Claims41
A method for measuring potency of a Clostridial neurotoxin, said method comprising:
- injecting a Clostridial neurotoxin into a muscle of a mammal;
- subjecting said mammal to a stimulus;
- and
- monitoring a pinna reflex response of said mammal to said stimulus to measure the potency of the Clostridial neurotoxin;
- wherein said monitoring includes measuring a latency of the response.
2 more elements
A method for measuring potency of a Clostridial neurotoxin, said method comprising:
- injecting a Clostridial neurotoxin into a muscle of each of a plurality of mammals, each mammal being provided with a different dose level of Clostridial neurotoxin;
- subjecting said mammals to a stimulus and;
- monitoring a pinna reflex response of said mammals to said stimulus to measure the potency of the Clostridial neurotoxin;
- wherein said monitoring includes measuring a latency of the response.
1 more element
Dependencies are inferred from the claim text.