Hedgehog interacting proteins and uses related thereto
AssigneePresident and Fellows of Harvard College
InventorsAndrew P. McMahon, Pao-Tien Chuang
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Abstract
The present invention concerns the discovery of a new family of hedgehog binding proteins, refered to herein as “hedgehog interacting proteins” or “HIPs”, which are demonstrated to bind to hedgehog polypeptides with high affinity. As described herein, the vertebrate HIP proteins exhibit spatially and temporally restricted expression domains indicative of important roles in hedgehog-mediated induction.
Claims14
An isolated and/or recombinantly produced hedgehog interacting protein (HIP) polypeptide, wherein said HIP polypeptide binds to a hedgehog protein and inhibits hedgehog signaling, and wherein said HIP polypeptide comprises a HIP amino acid sequence encoded by a nucleic acid that hybridizes under stringent conditions of 6.0×SSC at 45° C. which hybridization is maintained during a wash step of 0.2×SSC at 65° C. to a sequence selected from any of SEQ ID. Nos. 1, 2, 3, or 4.
An isolated and/or recombinantly produced polypeptide comprising a HIP amino acid sequence that binds to a hedgehog protein, wherein said HIP amino acid sequence is at least 95% identical to a sequence selected from any of SEQ ID Nos. 5, 6, 7, or 8.
Dependencies are inferred from the claim text.