Melanocortin-1 receptor and methods of use
AssigneeOrigene Technologies, Inc.
InventorsYoumin Shu, Xuan Li, Anthony C. Yee, Gilbert Jay
Life of this patent
Estimating the term…
Abstract
The present invention relates to all facets of novel polynucleotides for melanocortin-1 receptors, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions especially relating to melanocortin-1, such as melanoma, pigmentation disorders and conditions, inflammation, etc.
Claims14
An isolated polynucleotide comprising, a polynucleotide sequence coding without interruption for a human MCR-1C (melanocortin receptor 1C), or the complete complement to said polynucleotide sequence,
- said MCR-1C having 84% or more amino acid sequence identity along its entire length to the sequence consisting of amino acids 1–316 of SEQ ID NO 2, and 90% or more amino acid sequence identity along its entire length to the sequence consisting of amino acids 317–398 of SEQ ID NO 2, and which has ligand-binding activity, G-protein binding activity, or cAMP production activity, wherein said polynucleotide sequence coding for human MCR-1C hybridizes under high stringency conditions to the complete complement of SEQ ID NO:
- 1 from nucleotide position 342–1535, and the conditions comprise overnight incubation in 5X SSC, 0.5% SDS, 100 μ/ml denatured salmon sperm DNA and 50% formamide, at 42° C. followed by washing in 0.1% SSC and 0.1% SDS for 30 min at 65° C.
An isolated polynucleotide comprising a polynucleotide sequence coding for amino acids 367–398 of SEQ ID NO 2.
Dependencies are inferred from the claim text.