Polynucleotides encoding human vascular endothelial growth factor 2
AssigneeHuman Genome Sciences, Inc.
InventorsCraig A. Rosen, Jing-Shan Hu, Liang Cao
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Abstract
Disclosed is a human VEGF2 polypeptide and DNA (RNA) encoding such VEGF2 polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonist against such polypeptide. Also disclosed is a method of using such polypeptide for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antagonists to inhibit tumor growth, inflammation and to treat diabetic retinopathy, rheumatoid arthritis and psoriasis. Diagnostic methods for detecting mutations in the VEGF2 coding sequence and alterations in the concentration of VEGF2 protein in a sample derived from a host are also disclosed.
Claims24
An isolated polynucleotide comprising a nucleic acid sequence encoding the VEGF-2 polypeptide of SEQ ID NO:
- 2.
An isolated polynucleotide comprising a nucleotide sequence encoding the VEGF-2 polypeptide encoded by the cDNA contained in ATCC Deposit No. 97149.
An isolated polynucleotide comprising a nucleotide sequence encoding a VEGF-2 polypeptide comprising amino acids 85 to 165 of SEQ ID NO:2, which includes the eight conserved cysteines at amino acids 85, 110, 116, 119, 120, 127, 163, and 165.
An isolated polynucleotide comprising the nucleic acid sequence encoding a heterologous VEGF-2 polypeptide, wherein said polypeptide is isolated from the supernatant of cells engineered to express the polypeptide of SEQ ID NO:2, wherein the heterologous VEGF-2 polypeptide is generated by the expression of SEQ ID NO:2.
An isolated polynucleotide comprising the nucleic acid sequence encoding a polypeptide isolated from the supernatant of cells engineered to express a heterologous VEGF-2 polypeptide encoded by the cDNA contained in ATCC Deposit No. 97149, wherein the heterologous VEGF-2 polypeptide is generated by the expression of SEQ ID NO:2.
A purified polypeptide comprising a polypeptide encoded by the nucleotide sequence contained in ATCC Deposit No. 97149.
Dependencies are inferred from the claim text.