Method for detecting IGFBP-4 protease without detecting IGFBP-4 protease/proMBP Complex
AssigneesMayo Foundation for Medical Education and Research, Como Holdings APS
InventorsMichael Toft Overgaard, Claus Oxvig, Cheryl A. Conover
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Abstract
Methods for screening for altered focal proliferation states in non-pregnant patients, which include detecting levels of pregnancy-associated plasma protein-A (PAPP-A) are described. Methods for identifying agents that alter the protease activity of PAPP-A, and pharmaceutical compositions and medical devices that include such agents are also described.
Claims1
A method for detecting PAPP-A- in a biological sample comprising contacting said biological sample with an antibody having specific binding affinity for PAPP-A-, but not PAPP-A-/pro major basic protein complex, to detect PAPP-A- in said biological sample.
Dependencies are inferred from the claim text.