Anti-mammalian CX3C cytokine antibodies
AssigneeSchering Corporation
InventorsGerard T. Hardiman, Devora L. Rossi, Kevin B. Bacon, Fernando J. Bazan, Thomas B. Schall, Albert Zlotnik
Life of this patent
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Abstract
Nucleic acids encoding a new family of chemokines, the CX3C family, from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related diagnostic kits are also provided.
Claims23
An isolated antibody or antigen-binding fragment thereof which specifically binds to a polypeptide wherein said polypeptide
- a) chemoattracts peripheral blood monocytes or T-cells,
- b) consists of an amino acid sequence comprising at least 95% sequence identity to residues 25 to 397 of the amino acid sequence set forth in SEQ ID NO:
- 4, and
- c) comprises a chemokine domain identical to residues 25 to 100 of the amino acid sequence set forth in SEQ ID NO:
- 4.
An isolated antibody or antigen-binding fragment thereof which specifically binds to a polypeptide consisting of an amino acid sequence set forth in SEQ ID NO:
- 4.
An antibody or antigen-binding fragment thereof, that specifically binds to a polypeptide consisting of Gln25 to Gly100 of the amino acid sequence set forth in SEQ ID NO:
- 4.
An antibody or antigen-binding fragment thereof that specifically binds to a polypeptide consisting of Gln25 to Gly100 of the amino acid sequence set forth in SEQ ID NO:
- 4, wherein the antibody is raised against a purified or recombinantly produced polypeptide comprising Gln25 to Gly100 of the amino acid sequence set forth in SEQ ID NO:
- 4.
An antibody or antigen-binding fragment thereof that specifically binds to a polypeptide consisting of Gln25 to Gly100 of the amino acid sequence set forth in SEQ ID NO:
- 4, wherein the antibody is raised against a purified or recombinantly produced polypeptide comprising a mature polypeptide comprising the amino acid sequence set forth in SEQ ID NO:
- 4.
An isolated monoclonal antibody that binds specifically to a polypeptide consisting of amino acids 25–397 of SEQ ID NO:
- 4.
A pharmaceutical composition comprising an isolated monoclonal antibody that binds specifically to a polypeptide consisting of amino acids 25–397 of SEQ ID NO:
- 4 and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.