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US 7,115,368 B2Granted
Diagnosis and treatment of cancer using mammalian pellino polypeptides and polynucleotides
AssigneeAmgen SF, LLC
InventorsScott Powers, David Mu, Phil Xiang, Yue Peng
Life of this patent
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Abstract
The present invention provides methods, reagents, and kits for diagnosing and treating cancer in a mammal, e.g., a human. This invention is based upon the discovery that Pellino 1 or 2 is overexpressed and/or amplified in cancer. Methods to detect cancer or a propensity to develop cancer, to monitor the efficacy of a cancer treatment, and to treat cancer, by inhibiting the expression and/or activity of Pellino 1 or 2 in a cancer cell are included.
Claims4
A method of detecting epithelial cancer cells in a biological sample from a mammal, the method comprising the steps of:
- (a) providing the biological sample from the mammal;
- and
- (b) detecting an increase in copy number of a gene encoding SEQ ID NO:4 in the biological sample compared to control, thereby detecting the presence of epithelial cancer cells in the biological sample.
Dependencies are inferred from the claim text.