Attenuated Salmonella strain used as a vehicle for oral immunization
AssigneeGesellschaft fuer Biotechnologische Forschung mbH (GBF)
InventorsAyub Darji, Carlos A. Guzman, Kenneth Timmis, Siegfried Weiss, Birgit Gerstel, Trinad Chakraborty, Petra Wachholz, Jürgen Wehland
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Abstract
The present invention is directed to an attenuated Salmonella comprising a eukaryotic expression vector for delivery of the eukaryotic expression vector to a eukaryotic cell. Delivery may be to eukaryotic cells cultured in vitro or to cells in vivo, such as by oral administration of the attenuated Salmonella comprising the eukaryotic expression vector.
Claims15
An attenuated Salmonella strain comprising a eukaryotic expression vector, wherein said vector comprises a eukaryotic promoter and a heterologous DNA encoding a heterologous polypeptide, wherein said DNA is under the control of said eukaryotic promoter, wherein the attenuation is suitable for administration to a vertebrate, and wherein said administration to said vertebrate of said attenuated Salmonella strain results in expression of said polypeptide by said vertebrate and generates an immune response by said vertebrate to said polypeptide.
Dependencies are inferred from the claim text.