Back to results
US 7,115,265 B1Granted
Four genetic tumor markers specific for human glioblastoma
AssigneeDuke University
InventorsGregory J. Riggins, Anita Lal, William T. Loging
Life of this patent
Estimating the term…
Abstract
ABCC3, GPNMB, NNMT, and SEC61γ are expressed at higher levels in glioblastoma than in normal brain tissue. These four genes and their expression products are useful for diagnosing and treating glioblastoma and for identifying potential anticancer drugs.
Claims7
A method of specifically delivering a reagent to a glioblastoma, comprising the step of:
- contacting cells of the glioblastoma with an antibody which is conjugated to a reagent, wherein the antibody specifically binds to an extracellular epitope of glycoprotein (transmembrane) nmb (GPNMB) (SEQ ID NO:17), whereby the reagent is delivered to the cell.
Dependencies are inferred from the claim text.