Methods for treatment of tumors and metastases using a combination of anti-angiogenic and immuno therapies
AssigneesThe Scripps Research Institute, EMD Lexigen Research Center Corp.
InventorsHolger N. Lode, Ralph A. Reisfeld, David A. Cheresh, Stephen D. Gillies
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Abstract
The invention teaches methods for treating tumors and tumor metastases in a mammal comprising administering, to a mammal in need of treatment, a therapeutic amount of an antagonist sufficient to inhibit angiogenesis in combination with a therapeutic amount of anti-tumor immunotherapeutic agent, such as a anti-tumor antigen antibody/cytokine fusion protein having a cytokine and a recombinant immunoglobulin polypeptide chain sufficient to elicit a cytokine-specific biological response.
Claims14
A therapeutic composition comprising at least one angiogenesis inhibiting agent, which is an αvβ3 antagonist;
- and at least one anti-tumor immunotherapeutic agent, which is a fusion protein comprising cytokine IL-2 and an Ig heavy chain that immunoreacts with a tumor associated antigen target.
A kit for treating a tumor cell in a tumor or tumor metastases comprising a package comprising:
- a) an angiogenesis inhibiting agent, which is an αvβ3 antagonist capable of inhibiting angiogenesis in said tumor or said tumor metastases;
- b) an anti-tumor immunotherapeutic agent, which is a fusion protein comprising cytokine IL-2 and an Ig heavy chain that immunoreacts with the tumor associated antigen target;
- and
- c) instructions for using the agents in methods to treat tumors and tumor metastases.
Dependencies are inferred from the claim text.