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AssigneesHuman Genome Sciences, Inc., SmithKline Beecham Corporation, The Regents of the University of Michigan
InventorsVishva M. Dixit, Wei-Wu He, Kristine K. Kikly, Steven M. Ruben
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Human ICE LAP-6 polypeptides and DNA (RNA) encoding such ICE LAP-6 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such ICE LAP-6 for the treatment of a susceptibility to viral infection, tumorogenesis and to diseases and defects in the control embryogenesis and tissue homeostasis, and the nucleic acid sequences described above may be employed in an assay for ascertaining such susceptibility. Antagonists against such ICE LAP-6 and their use as a therapeutic to treat Alzheimer's disease, Parkinson's disease, rheumatoid arthritis, septic shock, sepsis, stroke, chronic inflammation, acute inflammation, CNS inflammation, osteoporosis, ischemia reperfusion injury, cell death associated with cardiovascular disease, polycystic kidney disease, apoptosis of endothelial cells in cardiovascular disease, degenerative liver disease, MS, ALS, cererbellar degeneration, ischemic injury, myocardial infarction, AIDS, myelodysplastic syndromes, aplastic anemia, male pattern baldness, and head injury damage are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the interleukin-1 beta converting enzyme apoptosis proteases and for detecting altered levels of the polypeptide in a host.
An isolated protein which comprises amino acid residues 2 to 416 of SEQ ID NO:1.
An isolated protein comprising a polypeptide sequence which is at least 95% identical to amino acid residues 2 to 416 of SEQ ID NO:1, wherein said protein induces apoptosis.
An isolated protein consisting of at least 30 contiguous amino acid residues of amino acids 1 to 416 of SEQ ID NO:1 wherein said isolated protein binds to an antibody that binds to amino acid residues 1 to 416 of SEQ ID NO:
An isolated protein which comprises the amino acid sequence of the full-length polypeptide encoded by the cDNA contained in ATCC™ Deposit No. 95590, excepting the N-terminal methionine.
An isolated protein comprising a polypeptide sequence which is at least 95% identical to the amino acid sequence of the full-length polypeptide encoded by the cDNA contained in ATCC™ Deposit No. 95590, excepting the N-terminal methionine, wherein said protein induces apoptosis.
An isolated protein consisting of at least 30 contiguous amino acid residues of the full-length polypeptide encoded by the cDNA contained in ATCC™ Deposit No. 95590 wherein said isolated protein binds to an antibody that binds to the full-length polypeptide encoded by the cDNA contained in ATCC™ Deposit No. 97590.
Dependencies are inferred from the claim text.