Back to results
US 7,115,259 B2Granted
Use of cytokines and mitogens to inhibit pathological immune responses
AssigneeUniversity of Southern California
InventorDavid A. Horwitz
Life of this patent
Estimating the term…
Abstract
The invention is generally related to methods of treating autoimmune diseases, including both antibody-mediated and cell-mediated disorders.
Claims23
A method for treating an autoimmune disorder in a patient comprising:
- a) removing peripheral blood mononuclear cells (PBMC) from said patient;
- b) treating said cells with a regulatory composition to generate regulatory T cells, said regulatory composition comprising anti-CD2 and anti-CD3;
- and;
- c) reintroducing said regulatory T cells to said patient to suppress an aberrant immune response.
1 more element
A method for treating an autoimmune disorder in a patient comprising:
- a) removing peripheral blood mononuclear cells (PBMC) from said patient;
- b) treating said cells with a regulatory composition to induce said cells to produce immunosuppressive levels of TGF-β;
- said regulatory composition comprising anti-CD2 and anti-CD3;
- and;
- c) reintroducing said cells to said patient to suppress aberrant immune responses.
2 more elements
Dependencies are inferred from the claim text.