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US 7,115,252 B2Granted
Therapeutic compositions and methods of use thereof
OwnerMilton Hodoshinventor
Life of this patent
Estimating the term…
Abstract
A method and composition for the restoration and maintenance of gingival and periodontal health are provided. The composition includes a potassium as an essential ingredient, which acts as an anti-bacterial agent. In some embodiments, the compositions include an osmotic agent other than potassium.
Claims44
A method for inhibiting the formation of plaque of the gingivo-dental anatomy in a subject, the method comprising the step of:
- periodically applying an effective amount of a composition containing potassium as an ingredient to a region of the gingivo-dental anatomy of the subject, and an osmotic agent, the concentration of the potassium containing compound of at least 10 weight percent up to the saturation level of the potassium containing compound, wherein the osmotic agent is selected from the group consisting of methylisosorbide, dimethylisosorbide, ethylisosorbide, diethylisosorbide, isopropylisosorbide, diisopropylisosorbide, butylisosorbide, dibutylisosorbide, methylethylisosorbide, methylpropylisosorbide, methylbutylisosorbide, ethylpropylisosorbide and ethylbutylisosorbide, and combinations thereof.
A method for inhibiting periodontal disease, comprising:
- applying an effective amount of a mouthwash to a region of the gingivo-dental anatomy of a subject, the mouthwash containing a concentration of a potassium containing compound and containing an osmotic agent, such that the potassium inhibits the formation of plaque-forming bacteria in the gingivo-dental anatomy, the concentration of the potassium containing compound of at least 10 weight percent up to the saturation level of the potassium containing compound wherein the osmotic agent is selected from the group consisting of methylisosorbide, dimethylisosorbide, ethylisosorbide, diethylisosorbide, isopropylisosorbide, diisopropylisosorbide, butylisosorbide, dibutylisosorbide, methylethylisosorbide, methylpropylisosorbide, methylbutylisosorbide, ethylpropylisosorbide and ethylbutylisosorbide, and combinations thereof.
A method for inhibiting the formation of plaque of the gingivo-dental anatomy in a subject, the method comprising the step of:
- periodically applying an effective amount of a composition containing potassium as an ingredient to a region of the gingivo-dental anatomy of the subject, and an osmotic agent, the concentration of the potassium containing compound is in a range of 10–20 weight percent wherein the osmotic agent is selected from the group consisting of methylisosorbide, dimethylisosorbide, ethylisosorbide, diethylisosorbide, isopropylisosorbide, diisopropylisosorbide, butylisosorbide, dibutylisosorbide, methylethylisosorbide, methylpropylisosorbide, methylbutylisosorbide, ethylpropylisosorbide and ethylbutylisosorbide, and combinations thereof.
A method for inhibiting periodontal disease, comprising:
- applying an effective amount of a mouthwash to a region of the gingivo-dental anatomy of a subject, the mouthwash containing a concentration of a potassium containing compound and containing an osmotic agent, such that the potassium inhibits the formation of plaque-forming bacteria in the gingivo-dental anatomy, the concentration of the potassium containing compound is in a range of 10–20 weight percent wherein the osmotic agent is selected from the group consisting of methylisosorbide, dimethylisosorbide, ethylisosorbide, diethylisosorbide, isopropylisosorbide, diisopropylisosorbide, butylisosorbide, dibutylisosorbide, methylethylisosorbide, methylpropylisosorbide, methylbutylisosorbide, ethylpropylisosorbide and ethylbutylisosorbide, and combinations thereof.
A method for inhibiting the formation of plaque of the gingivo-dental anatomy in a subject, the method comprising the step of:
- periodically applying an effective amount of a composition containing potassium as an ingredient to a region of the gingivo-dental anatomy of the subject, and an osmotic agent, wherein the composition contains potassium from potassium nitrate, and the concentration of the potassium containing compound is about 35 weight percent wherein the osmotic agent is selected from the group consisting of methylisosorbide, dimethylisosorbide, ethylisosorbide, diethylisosorbide, isopropylisosorbide, diisopropylisosorbide, butylisosorbide, dibutylisosorbide, methylethylisosorbide, methylpropylisosorbide, methylbutylisosorbide, ethylpropylisosorbide and ethylbutylisosorbide, and combinations thereof.
A method for inhibiting periodontal disease, comprising:
- applying an effective amount of a mouthwash to a region of the gingivo-dental anatomy of a subject, the mouthwash containing a concentration of a potassium containing compound and containing an osmotic agent, such that the potassium inhibits the formation of plaque-forming bacteria in the gingivo-dental anatomy, wherein the composition contains potassium from potassium nitrate, and the concentration of the potassium containing compound is about 35 weight percent wherein the osmotic agent is selected from the group consisting of methylisosorbide, dimethylisosorbide, ethylisosorbide, diethylisosorbide, isopropylisosorbide, diisopropylisosorbide, butylisosorbide, dibutylisosorbide, methylethylisosorbide, methylpropylisosorbide, methylbutylisosorbide, ethylpropylisosorbide and ethylbutylisosorbide, and combinations thereof.
A method for inhibiting the formation of plaque of the gingivo-dental anatomy in a subject, the method comprising the step of:
- periodically applying an effective amount of a composition containing potassium as an ingredient to a region of the gingivo-dental anatomy of the subject, and an osmotic agent, wherein the composition contains potassium from potassium nitrate, and the concentration of the potassium containing compound is in a range from about 3 weight percent up to the saturation level of the potassium containing compound wherein the osmotic agent is selected from the group consisting of methylisosorbide, dimethylisosorbide, ethylisosorbide, diethylisosorbide, isopropylisosorbide, diisopropylisosorbide, butylisosorbide, dibutylisosorbide, methylethylisosorbide, methylpropylisosorbide, methylbutylisosorbide, ethylpropylisosorbide and ethylbutylisosorbide, and combinations thereof.
A method for inhibiting periodontal disease, comprising:
- applying an effective amount of a mouthwash to a region of the gingivo-dental anatomy of a subject, the mouthwash containing a concentration of a potassium containing compound and containing an osmotic agent, such that the potassium inhibits the formation of plaque-forming bacteria in the gingivo-dental anatomy, wherein the composition contains potassium from potassium nitrate, and the concentration of the potassium containing compound is in a range from about 3 weight percent up to the saturation level of the potassium containing compound wherein the osmotic agent is selected from the group consisting of methylisosorbide, dimethylisosorbide, ethylisosorbide, diethylisosorbide, isopropylisosorbide, diisopropylisosorbide, butylisosorbide, dibutylisosorbide, methylethylisosorbide, methylpropylisosorbide, methylbutylisosorbide, ethylpropylisosorbide and ethylbutylisosorbide, and combinations thereof.
A method for inhibiting the formation of plaque of the gingivo dental anatomy in a subject, the method comprising the step of:
- periodically applying an effective amount of a composition containing potassium as an ingredient to a region of the gingivo-dental anatomy of the subject, and an osmotic agent, wherein the concentration of the potassium containing compound is at least about 3 weight percent and wherein the potassium containing compound is selected from the group consisting of potassium phosphate, potassium nitrate, potassium bicarbonate, potassium biphthalate, potassium chromate, potassium acetate, potassium dichromate, potassium chromium sulfate, potassium citrate, potassium thiocyanate, potassium alum, potassium bitartrate, potassium bromate, potassium carbonate, potassium chlorate, potassium chloroglatinate, potassium hydroxide, potassium perchlorate, potassium persulfate, potassium oxalate, potassium azide, potassium hydrogen sulfate, potassium iodate, potassium sodium tartrate and combinations thereof wherein the osmotic agent is selected from the group consisting of methylisosorbide, dimethylisosorbide, ethylisosorbide, diethylisosorbide, isopropylisosorbide, diisopropylisosorbide, butylisosorbide, dibutylisosorbide, methylethylisosorbide, methylpropylisosorbide, methylbutylisosorbide, ethylpropylisosorbide and ethylbutylisosorbide, and combinations thereof.
A method for inhibiting periodontal disease, comprising:
- applying an effective amount of a mouthwash to a region of the gingivo-dental anatomy of a subject, the mouthwash containing a concentration of a potassium containing compound and containing an osmotic agent, such that the potassium inhibits the formation of plaque-forming bacteria in the gingivo-dental anatomy, wherein the concentration of the potassium containing compound is at least about 3 weight percent and wherein the potassium containing compound is selected from the group consisting of potassium phosphate, potassium nitrate, potassium bicarbonate, potassium biphthalate, potassium chromate, potassium acetate, potassium dichromate, potassium chromium sulfate, potassium citrate, potassium thiocyanate, potassium alum, potassium bitartrate, potassium bromate, potassium carbonate, potassium chlorate, potassium chloroglatinate, potassium hydroxide, potassium perchlorate, potassium persulfate, potassium oxalate, potassium azide, potassium hydrogen sulfate, potassium iodate, potassium sodium tartrate and combinations thereof wherein the osmotic agent is selected from the group consisting of methylisosorbide, dimethylisosorbide, ethylisosorbide, diethylisosorbide, isopropylisosorbide, diisopropylisosorbide, butylisosorbide, dibutylisosorbide, methylethylisosorbide, methylpropylisosorbide, methylbutylisosorbide, ethylpropylisosorbide and ethylbutylisosorbide, and combinations thereof.
Dependencies are inferred from the claim text.