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US 7,115,248 B2Granted
Radiolabeled annexins
AssigneeNeoRx Corporation
InventorsSudhakar Kasina, John M Reno, Louis J Theodore
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Abstract
Radiolabeled annexin and modified annexin conjugates useful for imaging vascular thrombi are described. Methods for making and using such radiolabeled annexin conjugates are also provided.
Claims17
A conjugate comprising:
- an annexin;
- a NxSy chelating compound, wherein x is an integer from 2–4 and y is 1–4, or a N4 chelating compound;
- and
- a hexose moiety recognized by a mammalian liver receptor, wherein the hexose is conjugated to the annexin directly or via the chelating compound and the chelating compound is conjugated to the annexin directly or via the hexose moiety,
- wherein the annexin is not modified to provide an accessible sulfhydryl group to which the hexose moiety or the chelating compound is conjugated.
2 more elements
Dependencies are inferred from the claim text.