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AssigneeBattelle Memorial Institute
InventorsPaul D. Panetta, Richard A. Pappas, Brian J. Tucker
Estimating the term…
A fermention process is monitored by detecting ultrasound backscattered from the cells as a function of time. A transducer 46 is placed in a fermentor 30 and transmits ultrasound towards a reflecting surface 50. The transducer receives that portion of the ultrasound which reflects from the reflecting surface 50, as well as that portion of the ultrasound which backscatters from cells 34 between the transducer 46 and the reflecting surface 50. Signals from the transducer are conditioned and subsequently processed to provide output to a controller regarding the status of the fermentation process in real time. The backscattering measurements can be used to determine a growth phase transition, such as the transition between the logarithmic growth phase of the cells and their stationary phase.
A method comprising monitoring a fermentation process of a population of cells in a suspension or slurry by detecting ultrasound backscattered from the cells in the suspension or slurry, wherein the cells are selected from the group consisting of bacteria, yeast cells, fungi, and mammalian cells.
A method comprising:
A system comprising:
A method comprising determining cell growth during fermentation by monitoring ultrasound backscattered from the cells as a function of time.
A method comprising monitoring cell size and number per volume during fermentation by monitoring ultrasound backscattered from the cells as a function of time.
A method comprising:
Dependencies are inferred from the claim text.