Tissue electroperforation for enhanced drug delivery
AssigneeJohnson & Johnson Consumer Companies, Inc.
InventorsYing Sun, Ralph W. Oakeson, Stephen J. Wisniewski, Jonas C. T. Wang
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Abstract
The present invention relates to a method and a device for transporting a molecule through a mammalian barrier membrane of at least one layer of cells comprising the steps of: ablating the membrane with an electric current from a treatment electrode; and utilizing a driving force to move the molecule through the perforated membrane.
Claims18
A method for transporting a molecule through a mammalian barrier membrane of at least one layer of cells comprising the steps of:
- creating an air gap between a treatment electrode and said membrane;
- then ablating said membrane with an electric current from said treatment electrode wherein said electric current forms an electric arc within said air gap between said treatment electrode and said membrane;
- and
- utilizing a driving force to move said molecule through said ablated membrane, wherein said membrane is skin or a mucosal membrane.
The method of clam 1, wherein said membrane is a mucosal membrane selected from the group consisting of buccal, vaginal, and rectal membranes.
Dependencies are inferred from the claim text.